Sleep disturbance after cessation of cannabis administration in mice

Abstract Cannabis withdrawal syndrome (CWS) in humans is characterized by various somatic symptoms, including sleep disturbances. In the present study, we investigated sleep alterations in mice after the cessation of arachidonylcyclopropylamide (ACPA), a cannabinoid type 1 receptor agonist, administration. ACPA‐administered mice (ACPA mice) displayed an increased number of rearings after the cessation of ACPA administration compared to saline‐administered mice (Saline mice). Moreover, the number of rubbings was also decreased in ACPA mice compared with those of the control mice. Electroencephalography