A nomogram to predict conversion of laparoscopic surgery to laparotomy for Choledocholithiasis

Article type: Research Article

Keywords: Conversion, Laparoscopic surgery, Laparotomy, Nomogram, Choledocholithiasis

Authors: Yitao Zheng, Haoyang Lv, Zhuoqun Lin, Hongqi Shi, Xiaming Huang

Affiliations: https://ror.org/00rd5t069grid.268099.c0000 0001 0348 3990Department of Hepatobiliary Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000 Zhejiang Province China

License: © The Author(s) 2023 CC BY 4.0 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Article links: DOI: 10.1186/s12893-023-02275-1  |  PubMed: 38066500  |  PMC: PMC10709908

Relevance: Relevant: mentioned in keywords or abstract

Full text: PDF (1.6 MB)

Introduction

Approximately 3–18% of patients with gallbladder stones have secondary choledocholithiasis [ref. 1, ref. 2]. Previously, laparotomy was the gold standard treatment for choledocholithiasis, however, this procedure often required large abdominal incisions. Postoperative incision infections and pain are common in these patients, resulting in longer hospital stays [ref. 3]. With the development of laparoscopic technology, laparoscopic common bile duct exploration (LCBDE) surgery is favored by an increasing number of surgeons because this procedure is less invasive than open surgery, with a lower risk of infection and faster recovery for the patients [ref. 4]. Patients with common bile duct (CBD) stones sometimes also have intrahepatic bile duct (IHD) stones [ref. 1]. Laparoscopic hepatectomy (LH) has been shown to be safe for some patients with IHD stones [ref. 5, ref. 6]. Therefore, for patients with concomitant intrahepatic and extrahepatic bile duct stones, simultaneous LCBDE and LH procedures are required [ref. 7, ref. 8].

LCBDE and LH require proficiency in laparoscopic hepatobiliary system anatomy, skilled laparoscopic suturing and knot-tying, and endoscopic techniques [ref. 9]. Even when performed by experienced surgeons, there is a 5% probability of conversion to open surgery [ref. 10]. Conversion is neither a surgical complication nor a surgical failure. Rather, it is a change in the surgical approach. Blind continuation of laparoscopic surgery may lead to serious complications when circumstances make it inappropriate to continue [ref. 11]. Therefore, a scoring system is urgently needed to help surgeons choose between a more rational preoperative and intraoperative surgical approach in laparoscopic surgery for choledocholithiasis.

Our study aimed to establish a nomogram to evaluate the risk of conversion to open surgery in patients undergoing laparoscopic surgery for choledocholithiasis, thereby enabling surgeons to judge the complications of the procedure and reduce patient trauma.

Materials and methods

Patients

We collected medical records of patients who were diagnosed with choledocholithiasis with or without hepatolithiasis and underwent laparoscopic surgery from January 2015 to September 2020 at the First Affiliated Hospital of Wenzhou Medical University. The exclusion criteria were as follows: (1) lack of preoperative clinical data, (2) intraoperative or postoperative diagnosis of gallbladder, bile duct, and ampullary tumors, (3) congenital anomalies of the hepatobiliary system, (4) Mirizzi Syndrome.

The First Affiliated Hospital of Wenzhou Medical University’s Ethics Committee approved this study (No.:Y(2022).R194). Due to the retrospective nature of this study and the anonymized data of all patients, the Ethics Committee of the First Affiliated Hospital of Wenzhou Medical University waived the requirement for informed consent.

Surgical procedures

LCBDE: all patients underwent surgery by either associate chief surgeons or chief surgeons with more experience. After a successful anesthesia, the patient is placed in a supine position. Standard disinfection measures are followed and a 10 mm arc-shaped incision is made at the lower edge of the navel. The pneumoperitoneum needle is then successfully inserted into the abdominal cavity, injecting carbon dioxide to establish 15 mmHg of pneumoperitoneum. A 10 mm diameter Trocar is punctured into the abdominal cavity, followed by the placement of a laparoscope. The patient’s position is then adjusted to a semi-fowler’s with the right side slightly elevated. Based on the location of the liver and gallbladder, an approximately 10 mm long incision is made beneath the xiphoid process on the right side, along with two other incisions, each about 5 mm long, below the costal margin on the right mid-clavicular line and the right mid-axillary line respectively. Corresponding Trocars with diameters of 10 mm and 5 mm are punctured into the abdominal cavity. Under laparoscopy, the common bile duct is exposed. A longitudinal incision of about 1.5 cm is made on the upper segment of the common bile duct to the duodenum. Stones are initially removed using stone forceps, followed by inspection with a choledochoscope. Sterile saline washing, stone retrieval baskets, and holmium laser lithotripsy are among the methods used for stone removal until no stones are detected under the choledochoscope.

LH: after anesthesia, the patient is positioned in the supine position. The four-trocar technique is commonly used in most cases. As described above, a trocar is placed below the umbilicus to establish pneumoperitoneum, maintaining an intra-abdominal pressure of 12–15 mmHg. Additionally, a 5 mm trocar is placed below the costal margin along the midclavicular line on the right side and another along the right mid-axillary line. A 12 mm trocar is positioned below the xiphoid process. The liver parenchyma is excised using an ultrasonic scalpel, in conjunction with instruments like electrocautery, Hem-o-lock clips, and the Endo-Line Cutter. The falciform and coronary ligaments are severed with the ultrasonic scalpel. Careful dissection of the arteries and veins in the left lateral segment is performed, followed by clamping with Hem-o-lock clips, and then separation. The left hepatic vein is transected from the second hepatic portal, using clamps to separate it. The liver parenchyma is then transected transversely with an endolinear cutter. The excised specimen is placed into a specimen bag, crushed, and extracted through a 12 mm port. The liver’s cut surface is meticulously inspected to ensure there is no bleeding or bile leak, followed by thorough lavage of the abdominal cavity. A drainage tube is placed as per routine. A T-tube is usually placed postoperatively. The method for exploring the common bile duct and performing a cholecystectomy is the same as described.

Data collection

The demographic and clinical data, including age, sex, body mass index (BMI), diabetes, hypertension, previous upper abdominal surgery (PUAS), history of endoscopic retrograde cholangiopancreatography (ERCP), and pancreatitis were recorded. Laboratory blood test results included white blood cell count, albumin (ALB), total bilirubin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase levels. Preoperative abdominal ultrasonography, computed tomography, magnetic resonance imaging, or magnetic resonance cholangiopancreatography was evaluated by an experienced radiologist. The following data were collected: the maximum diameter of CBD stone, CBD stone’s location, The number of stones in CBD, IHD stone, gallbladder wall thickness, CBD wall thickness, the maximum diameter of CBD, and stone size/CBD size. All the included data were the most recent preoperative results for the patients. In addition, the type of surgery performed was also recorded.

Using the duodenum and pancreas as the boundary, we divided the stone locations into four parts: duodenal upper segment, duodenal posterior segment, pancreatic segment, and medial wall of the duodenum [ref. 12, ref. 13]. Some patients may have stones at more than one site simultaneously. The maximum diameter of CBD stone was defined as the transverse diameter perpendicular to the wall of the bile duct. The wall of the gallbladder was considered thickened if it was > 4 mm [ref. 14]. CBD wall thickness > 2 mm was defined as CBD wall thickening [ref. 15]. Patients with previous cholecystectomy were considered to have a gallbladder wall thickness of ≤4 mm and to have a history of PUAS. All patients underwent LCBDE surgery, and some had undergone laparoscopic cholecystectomy (LC), LH, or holmium laser lithotripsy simultaneously.

We concurrently computed the ratio between the maximum diameter of the bile duct stones and the maximum diameter of the common bile duct for each patient. By calculating the Youden’s Index, we found that the optimal cut-off value is 0.75.

In addition, we recorded the operative time, stone clearance rate, T-tube placement, mortality, incision infection, postoperative complications, duration of postoperative antibiotic use, and postoperative hospital stay to analyze the effect of conversion to laparotomy during the perioperative period.

Statistical analysis

IBM SPSS 23.0 (IBM USA) was used to process the data. According to the commonly used clinical cut-off points based on the relevant literature, some measurements in the original data were classified and transformed into count data, and the numerical values and percentages were used for statistical description. Normally distributed variables were expressed as mean ± standard deviation, and differences between groups were analyzed using the t-test. Variables with skewed distributions were expressed as medians (25th percentile, 75th percentile), and the Mann-Whitney test was used to assess differences between the two groups. Categorical variables were summarized as numbers and frequencies, and univariate analyses were performed using Fisher’s exact test or Pearson’s chi-square test. Univariate analysis was performed using the chi-square test or Fisher exact probability method to screen the relative risk factors. Multivariate logistic regression analysis (stepwise forward conditional) was used to screen the independent risk factors. All patients were randomly divided into a training group and a validation group in a 7:3 ratio. Multifactorial logistic regression analysis was conducted on the patients in the training group to construct a nomogram. The validation group was then used to assess the predictive performance of the nomogram. The “rms” package (R version 4.2.1) was used to establish the nomogram, and then bootstrap repeated sampling was used for internal verification and calibration curve drawing. To reduce overfitting bias, the nomogram model was internally verified using 1000 repeated samplings. The area under the receiver operating characteristic (ROC) curve (AUC) was used to evaluate model discrimination. Decision curve analysis (DCA) was used to quantify the net benefit under different threshold probabilities in the patient cohort, which can guide clinical decision-making. Across all tests, statistical significance was set at P < 0.05.

Results

Basic information

Figure 1 shows the flow chart for patient selection. A total of 867 patients were enrolled in the study cohort, of which 607 patients were assigned to the training group and the remaining 260 to the validation group. There were no significant differences in baseline characteristics between the two groups (P > 0.05) (Table 1). A total of 151 patients underwent conversion to open surgery. The reasons for conversion to laparotomy were as follows: (1) Anatomical difficulties in the gallbladder triangle(25.2%), (2) severe abdominal adhesions (27.8%), (3) difficulty in stone removal (23.2%), (4) excessive number of stones (4.6%), (5) difficulties stopping bleeding (8.6%), (6) bile duct duodenal fistula or gallbladder duodenal fistula (8.6%), and (7) severe liver atrophy (2.0%).

In the entire study population, the average age of the participants was 61.8 ± 14.4 years. Most CBD stones were located in the duodenal posterior and pancreatic segment, and 450 patients (51.9%) had two or more stones.

Univariate and multivariate analysis

Table 2 shows the univariate and multivariate logistic regression analysis of factors influencing conversion to laparotomy. The following 11 factors were included in the univariate logistic regression: Female, PUAS, ALB< 35 g/L, maximum diameter of stone ≥12 mm, medial wall of the duodenum stone, IHD stone, thickening of the gallbladder wall, thickening of CBD wall, diameter of CBD, stone size/CBD size ≥0.75, and simultaneous LH. Finally, in the multivariate logistic regression, the following seven factors were identified as independent risk factors for predicting conversion to laparotomy: PUAS, maximum diameter of stone ≥12 mm, medial wall of the duodenum stone, thickening of the gallbladder wall, thickening of CBD wall, stone size/CBD size ≥0.75 and simultaneous LH.

Construction of the nomogram

Combined with the above seven independent risk factors, a prediction model was constructed and presented in the form of a nomogram (Fig. 2). The scores included in the nomogram prediction model for PUAS, maximum diameter of stone ≥12 mm, medial wall of the duodenum stone, thickening of the gallbladder wall, thickening of CBD wall, stone size/CBD size ≥0.75 and simultaneous LH were 71, 43, 86, 75, 77, 33 and 100, respectively. The nomogram was scored from 0 to 450 points. We also calculated the total score of each patient and based on that, the Youden-derived optimal cut-off value for the nomogram was 119 points, the nomogram had a sensitivity of 72.5% and specificity of 79.4% at this threshold. Using this score as the boundary, we assigned patients below this score as low-risk patients and those above this score as high-risk patients.

The AUCs for the prediction nomogram was 0.813 (95% CI: 0.766–0.861) in the training (Fig. 3A) and 0.804 (95% CI: 0.737–0.871) in the validation group (Fig. 3B). The calibration curves of the training (Fig. 3C) and validation group (Fig. 3D) indicated the good consistency between the observed and predicted values, with the P-value for the Hosmer-Lemeshow test of 0.202 and 0.109, respectively. Furthermore, the nomogram-related DCA curves in the training (Fig. 4) showed good clinical application ability, suggesting a preferable positive net benefit.

Perioperative outcomes

Table 3 shows the perioperative outcomes of the conversion and non-conversion groups. The operative time, duration of postoperative antibiotic use, incidence of incision infection, and length of postoperative hospital stay were higher in the conversion group than in the non-conversion group. There were no significant differences in stone clearance rate, postoperative mortality, or complications between the two groups. More patients in the conversion group underwent T-tube placement during the operation.

Discussion

Accurate preoperative stratification and intraoperative conversion to open surgery are key factors for controlling the quality of laparoscopic surgery and patient safety [ref. 16]. Previous studies [ref. 10, ref. 17] have suggested that CBD edema, maximum stone diameter, multiple stones, and impacted stones are factors for conversion in LCBDE. However, they only predicted difficult factors without validation, and their clinical data were relatively limited. The seven independent factors in our nomogram can be easily obtained using preoperative abdominal imaging information and medical history. Additionally, we have conducted nomogram validations for patients undergoing different surgeries (the validation subjects being patients from the entire cohort). Supplementary figure represent subgroup validations for patients who simultaneously underwent LCBDE and either LC (A) or LH (B). Both subgroups showed high AUC values, indicating that the nomogram is applicable to patients undergoing the aforementioned surgeries.

In our cohort, 25 of the 41 patients who underwent conversion surgery because of dense abdominal adhesions had PUAS. PUAS can lead to extensive adhesions in the abdominal cavity and changes in the anatomical structure of the hepatic hilum. A previous autopsy confirmed that the incidence of abdominal adhesions after minor surgery, major surgery, and multiple abdominal surgeries were 51, 72, and 93%, respectively [ref. 18]. Wang et al. [ref. 1] found that the area with moderate to severe adhesions was very rich in vasculature, making the intraoperative surgical site anatomy difficult. Laparoscopic separation of adhesions is more likely to cause liver capsule injury and increase the risk of small intestine perforation, which makes the operation more complicated [ref. 19].

Tosun et al. [ref. 20] suggested that gallbladder wall thickening is the most sensitive indicator for conversion in LC. The thickening of the gallbladder wall often indicates the presence of acute or chronic inflammation. Chronic inflammation and/or acute inflammatory edema of the gallbladder often lead to an unclear anatomical relationship of the gallbladder triangle, or even “frozen” adhesion, making the operation more difficult. For patients with CBD stones, the occurrence of stone incarceration or repeated physical stimulation of stones to CBD wall easily causes inflammatory fibrosis of the CBD wall, resulting in local thickening [ref. 15]. In our study, we found that patients with localized thickening also had CBD edema during intraoperative exploration, resulting in brittleness of the CBD wall and its surrounding tissues. If laparoscopic exploration and suture are performed repeatedly at the edematous CBD, it easily leads to bleeding of the surrounding tissue of the bile duct during the operation and obstructs the operation field. Furthermore, it is also easy to cause postoperative bile leakage and increase the risk of complications [ref. 10].

In our nomogram, stone in the medial wall of the duodenum had a higher score (points = 86). Nobel et al. [ref. 21] showed that impaction of the medial wall of the duodenum stone was related to prolonged operative time and surgical failure in LCBDE. Because the lumen of the inner segment of the duodenum is small and the wall is thick, the stones in this area are easily impacted, and the removal basket and forceps for stone removal cannot penetrate this area along the wall of the bile duct or open it during the operation [ref. 12].

Xu et al. [ref. 10] found that large CBD stones were a risk factor for conversion to open surgery in LCBDE. However, there is no consensus on the definition of large CBD stones, and most researchers use a cut-off value between 10 and 15 mm [ref. 22, ref. 23]. Sharma et al. [ref. 22] and Oguz [ref. 24] suggested using the ratio of the stone size/CBD size> 1 to define large stones. However, the diameter of the stone in the above studies included the transverse diameter and the long diameter; some stones were oval and had a long diameter even larger than the diameter of the CBD. In this case, the ratio could not be used to evaluate the size of the stone. Therefore, in our study, the maximum diameter of the stone was defined as the maximum transverse diameter perpendicular to the CBD wall. If the ratio is too large, it can cause stone impactionand increase the difficulty of allowing the stone removal basket and forceps through, thus causing difficulty in stone removal. Therefore, we suggest that appropriate conversion to laparotomy is necessary in the case of large stones or intramural stones to reduce the injury to the patient caused by repeated stone removal. Simultaneous LH has a high score in the nomogram. Surgery for patients with IHD stones is more challenging than those with liver neoplasm because IHD stones can lead to liver inflammation, which further leads to perihepatic adhesion and anatomical distortion [ref. 25]. Fibrosis and atrophic changes in the liver parenchyma lead to deformation of the anatomical structure of the IHD, making the transection of the liver parenchyma difficult [ref. 26].

As shown in Table 3, the operation time, postoperative antibiotic use time, and postoperative hospital stay time in the conversion group were longer than the patients in the non-conversion group, but there were no significant differences in stone clearance, mortality, and postoperative complication rates. This is consistent with previous studies [ref. 10, ref. 16, ref. 27]. Patients who should be converted if the surgeon insists on continuing laparoscopic exploration, the patients’ blood vessels, organs, and biliary tract may be seriously injured [ref. 11, ref. 28, ref. 29]. Therefore, it is necessary to convert to laparotomy in time when the treatment effect is similar.

We propose that laparoscopic surgery should be actively performed in low-risk patients. However, we recommend that additional surgical plans, such as ERCP + LC and open surgery, should be made before surgery for high-risk patients. We also recommend allocating low-risk patients to junior surgeons and high-risk patients to senior surgeons.

Our study had certain limitations. Firstly, this was a retrospective study based on the patients’ database. Selection bias cannot be completely ruled out, and prospective data are needed to further validate our prediction model in the future. Secondly, this was a single-center study, so the generalizability of our nomogram needs to be further validated in multicenter studies. We did not include variables like the type of PUAS, characteristics of hepatolithiasis, and the presence or absence of emergency surgery.

Conclusion

Our study suggests seven independent risk factors for conversion to laparotomy in laparoscopic surgery for choledocholithiasis. We constructed a clinically effective and significant nomogram based on these factors. It can help surgeons evaluate the difficulty of surgery beforehand, optimize clinical decision-making, and provide a basis for timely conversion to open surgery.

References

1. Y Wang, X Bo, Y Wang, M Li, S Shen, T Suo, H Pan, H Liu, H Liu. Laparoscopic surgery for choledocholithiasis concomitant with calculus of the left intrahepatic duct or abdominal adhesions. Surg Endosc., 2017. [DOI | PubMed]
2. F Lammert, K Gurusamy, CW Ko, JF Miquel, N Mendez-Sanchez, P Portincasa, KJ van Erpecum, CJ van Laarhoven, DQ Wang. Gallstones. Nat Rev Dis Primers., 2016. [DOI | PubMed]
3. S Tazuma, M Unno, Y Igarashi, K Inui, K Uchiyama, M Kai, T Tsuyuguchi, H Maguchi, T Mori, K Yamaguchi. Evidence-based clinical practice guidelines for cholelithiasis 2016. J Gastroenterol., 2017. [DOI | PubMed]
4. K Gurusamy, SJ Sahay, AK Burroughs, BR Davidson. Systematic review and meta-analysis of intraoperative versus preoperative endoscopic sphincterotomy in patients with gallbladder and suspected common bile duct stones. Br J Surg., 2011. [DOI | PubMed]
5. X Ye, K Ni, X Zhou, K Xie, X Hong. Laparoscopic versus open left hemihepatectomy for hepatolithiasis. J Surg Res., 2015. [DOI | PubMed]
6. JM Namgoong, KH Kim, GC Park, DH Jung, GW Song, TY Ha, DB Moon, CS Ahn, S Hwang, SG Lee. Comparison of laparoscopic versus open left hemihepatectomy for left-sided hepatolithiasis. Int J Med Sci., 2014. [DOI | PubMed]
7. Z Zhang, Z Liu, L Liu, M Song, C Zhang, H Yu, B Wan, M Zhu, Z Liu, H Deng. Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones. Front Med., 2017. [DOI | PubMed]
8. Y Zhou, WZ Zha, XD Wu, RG Fan, B Zhang, YH Xu, CL Qin, J Jia. Biliary exploration via the left hepatic duct orifice versus the common bile duct in left-sided hepatolithiasis patients with a history of biliary tract surgery: a randomized controlled trial. Medicine (Baltimore)., 2018. [DOI | PubMed]
9. KS Savita, VK Bhartia. Laparoscopic CBD Exploration. Indian J Surg., 2010. [DOI | PubMed]
10. B Xu, YX Wang, YX Qiu, HB Meng, J Gong, W Sun, B Zhou, J He, T Zhang, WY Zheng. Risk factors and consequences of conversion to open surgery in laparoscopic common bile duct exploration. Surg Endosc., 2018. [DOI | PubMed]
11. K Beksac, N Turhan, E Karaagaoglu, O Abbasoglu. Risk factors for conversion of laparoscopic cholecystectomy to open surgery: a new predictive statistical model. J Laparoendosc Adv Surg Tech A., 2016. [DOI | PubMed]
12. H Jiang, SY Wang, XL Jin, JC Jin, HB Gu, FM Zhang. Surgical treatment of incarcerated calculi via laparoscopic bile duct exploration using laparotomy biliary lithotomy forceps. Exp Ther Med., 2016. [DOI | PubMed]
13. GA Kune. The influence of structure and function in the surgery of the biliary tract. Ann R Coll Surg Engl., 1970. [PubMed]
14. ASY Hu, R Menon, R Gunnarsson, A de Costa. Risk factors for conversion of laparoscopic cholecystectomy to open surgery – a systematic literature review of 30 studies. Am J Surg., 2017. [DOI | PubMed]
15. SJ Schulte, RL Baron, SA Teefey, CA Rohrmann, PC Freeny, WP Shuman, MA Foster. CT of the extrahepatic bile ducts: wall thickness and contrast enhancement in normal and abnormal ducts. AJR Am J Roentgenol., 1990. [DOI | PubMed]
16. C Paya-Llorente, C Domingo-Del Pozo, P Gonzalvez-Guardiola, S Santarrufina-Martinez, E Pareja-Ibars, A Martinez-Perez. Conversion to open surgery during laparoscopic common bile duct exploration: predictive factors and impact on the perioperative outcomes. HPB (Oxford)., 2022. [DOI | PubMed]
17. H Zhu, L Wu, R Yuan, Y Wang, W Liao, J Lei, J Shao. Learning curve for performing choledochotomy bile duct exploration with primary closure after laparoscopic cholecystectomy. Surg Endosc., 2018. [DOI | PubMed]
18. MA Weibel, G Majno. Peritoneal adhesions and their relation to abdominal surgery. A postmortem study. Am J Surg., 1973. [DOI | PubMed]
19. S Szomstein, E Lo Menzo, C Simpfendorfer, N Zundel, RJ Rosenthal. Laparoscopic lysis of adhesions. World J Surg., 2006. [DOI | PubMed]
20. A Tosun, KO Hancerliogullari, I Serifoglu, Y Capan, E Ozkaya. Role of preoperative sonography in predicting conversion from laparoscopic cholecystectomy to open surgery. Eur J Radiol., 2015. [DOI | PubMed]
21. H Noble, E Whitley, S Norton, M Thompson. A study of preoperative factors associated with a poor outcome following laparoscopic bile duct exploration. Surg Endosc., 2011. [DOI | PubMed]
22. SS Sharma, P Jain. Should we redefine large common bile duct stone?. World J Gastroenterol., 2008. [DOI | PubMed]
23. MA Almadi, M Eltayeb, S Thaniah, F Alrashed, MA Aljebreen, OR Alharbi, N Azzam, AM Aljebreen. Predictors of failure of endoscopic retrograde cholangiography in clearing bile duct stone on the initial procedure. Saudi J Gastroenterol., 2019. [DOI | PubMed]
24. O Uskudar, E Parlak, S Disibeyaz, AS Koksal, B Cicek, ZM Kilic, B Odemis, N Sasmaz. Major predictors for difficult common bile duct stone. Turk J Gastroenterol., 2013. [PubMed]
25. YK Kim, HS Han, YS Yoon, JY Cho, W Lee. Laparoscopic approach for right-sided intrahepatic duct stones: a comparative study of laparoscopic versus open treatment. World J Surg., 2015. [DOI | PubMed]
26. YS Yoon, HS Han, SH Shin, JY Cho, SK Min, HK Lee. Laparoscopic treatment for intrahepatic duct stones in the era of laparoscopy: laparoscopic intrahepatic duct exploration and laparoscopic hepatectomy. Ann Surg., 2009. [DOI | PubMed]
27. VV Grubnik, AI Tkachenko, VV Ilyashenko, KO Vorotyntseva. Laparoscopic common bile duct exploration versus open surgery: comparative prospective randomized trial. Surg Endosc., 2012. [DOI | PubMed]
28. K Singh, A Ohri. Laparoscopic cholecystectomy – is there a need to convert?. J Minim Access Surg., 2005. [DOI | PubMed]
29. S Kala, S Verma, G Dutta. Difficult situations in laparoscopic cholecystectomy: a multicentric retrospective study. Surg Laparosc Endosc Percutan Tech., 2014. [DOI | PubMed]