Δ9-tetrahydrocannabinol discrimination: Effects of route of administration in mice

Abstract We examined if route of administration altered THC’s discriminative stimulus in mice. i.p., p.o., s.c., and aerosolized THC fully substituted for i.p. THC. THC’s time course was similar for i.p., s.c., and p.o. routes of administration. Aerosolized THC had a quicker onset and shorter duration of effects. Multiple routes of THC administration produced THC-like psychoactive effects in mice. Article type: Research Article Keywords: Cannabinoid, Delta-9-tetrahydrocannabinol, Drug discrimination, Route of administration, Sex differences Authors: Julie A. Marusich, Jenny L. Wiley