Not all vaping is the same: differential pulmonary effects of vaping cannabidiol versus nicotine

Abstract Rationale: Vaping has become a popular method of inhaling various psychoactive substances. While evaluating respiratory effects of vaping have primarily focused on nicotine-containing products, cannabidiol (CBD)-vaping is increasingly becoming popular. It currently remains unknown whether the health effects of vaping nicotine and cannabinoids are similar. Objectives: This study compares side by side the pulmonary effects of acute inhalation of vaporised CBD versus nicotine. Methods: In vivo inhalation study in mice and in vitro cytotoxicity experiments with human cells were