Dynamic aphasia as an early sign of corticobasal degeneration: Clinico-radio-pathological correlation
Abstract A 72-year-old man presented with a 6-month history of decreased voluntary speech. Sparse speech and decreased word fluency were…
Yuko Saito
Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study
Abstract Purpose: Due to the indistinguishable clinical features of corticobasal syndrome (CBS), the antemortem differentiation between corticobasal degeneration (CBD) and…
Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseases
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-024-01758-3. Article type: Research Article Keywords: Cerebrospinal fluid, Biomarkers,…
Human tauopathy-derived tau strains determine the substrates recruited for templated amplification
Abstract Tauopathies are a subset of neurodegenerative diseases characterized by abnormal tau inclusions. Specifically, three-repeat tau and four-repeat tau in…
Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies
Abstract The mechanism of neuronal dysfunction via tau aggregation in tauopathy patients is controversial. In Alzheimer’s disease (AD), we previously…
Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain
Abstract Background: Intracytoplasmic inclusions composed of filamentous tau proteins are defining characteristics of neurodegenerative tauopathies, but it remains unclear why…