Transcriptional Mapping of the Human Cannabinoid Receptor 1 (CNR1) Gene Promoter
Abstract The transcriptional regulation of the cannabinoid receptor 1 (CB1R) by promoter/enhancer elements and transcription factors is an area of…
Wesley M. Raup-Konsavage
Pharmacokinetics of Cannabinoids Delivered by Diverse Routes in Rodents
Abstract Background: The rising popularity of medicinal and recreational use of Cannabis sativa L. has prompted a parallel increase in…
Orally Administered CBD/CBG Hemp Extract Reduces Severity of Ulcerative Colitis and Pain in a Murine Model
Abstract Background: Ulcerative colitis (UC) is an autoimmune disorder characterized by inflammation of the mucosa that gives rise to a…
The Pharmacology of Cannabinoids in Chronic Pain
Abstract Background: Our objective was to provide an overview of the currently available scientific and clinical data supporting the use…
Cannabinoid-Induced Immunogenic Cell Death of Colorectal Cancer Cells Through De Novo Synthesis of Ceramide Is Partially Mediated by CB2 Receptor
Abstract Mounting evidence demonstrates that cannabinoids have anti-cancer properties. The mechanism by which the cannabinoids induce cell death is still…
The Potential of Cannabichromene (CBC) as a Therapeutic Agent
Abstract SIGNIFICANCE STATEMENT: Cannabichromene (CBC) has been suggested to have disparate therapeutic benefits such as anti-inflammatory, anticonvulsant, antibacterial, and antinociceptive…
High Cannabigerol Hemp Extract Moderates Colitis and Modulates the Microbiome in an Inflammatory Bowel Disease Model
Abstract SIGNIFICANCE STATEMENT: Using the dextran sodium sulfate model of colitis, the authors show that treatment with high cannabigerol hemp…
Effect of Hemp Extraction Procedures on Cannabinoid and Terpenoid Composition
Abstract A variety of techniques have been developed to extract hemp phytochemicals for research and consumption. Some of the most…
Effects of cannabidiol, with and without ∆9-tetrahydrocannabinol, on anxiety-like behavior following alcohol withdrawal in mice
Abstract Introduction: Alcohol use disorder (AUD) is commonly associated with anxiety disorders and enhanced stress-sensitivity; symptoms that can worsen during…
Systematic review of drug-drug interactions of delta-9-tetrahydrocannabinol, cannabidiol, and Cannabis
Abstract Background: The recent exponential increase in legalized medical and recreational cannabis, development of medical cannabis programs, and production of…