Cannabinoids and opioid consumption in cancer pain: a systematic review and meta-analysis
Abstract Background: Opioids are the mainstay of cancer-related pain management but are limited by adverse effects and clinical complexity. Cannabinoids…
Teodora Alexa-Stratulat
MRI-Based Radiomics Reveals Cannabinoid-Associated Tumor Phenotypes in a Murine Breast Cancer Model
Abstract Introduction and Aim: Assessment of antitumor activity in preclinical models remains challenging when relying solely on conventional size-based imaging,…
Multifaced roles of cannabinoid therapy in cancer: balancing analgesia, antitumor potential, and systemic toxicity
Abstract Introduction: Cannabinoids hold promise in oncology for symptom relief and antitumor effects, though concerns about safety and efficacy persist.…
JWH-182: a safe and effective synthetic cannabinoid for chemotherapy-induced neuropathic pain in preclinical models
Abstract Chemotherapy-induced neuropathic pain (CINP), a condition with unmet treatment needs, affects over half of cancer patients treated with chemotherapeutics.…
The potential neuroprotective effects of cannabinoids against paclitaxel-induced peripheral neuropathy: in vitro study on neurite outgrowth
Abstract Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a shared burden for 68.1% of oncological patients undergoing chemotherapy with Paclitaxel (PTX).…
Should oncologists trust cannabinoids?
Abstract Cannabis enjoyed a “golden age” as a medicinal product in the late 19th, early 20th century, but the increased…
The Therapeutic Potential of the Endocannabinoid System in Age-Related Diseases
Abstract The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian physiology. ECS has gained substantial interest since growing evidence…
Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?
Abstract The most important discoveries in pharmacology, such as certain classes of analgesics or chemotherapeutics, started from natural extracts which…
Challenges and Opportunities in Preclinical Research of Synthetic Cannabinoids for Pain Therapy
Abstract Cannabis has been used in pain management since 2900 BC. In the 20th century, synthetic cannabinoids began to emerge,…