Genotype–Specific Safety and Pharmacokinetics of Cannabidiol in Healthy Volunteers
Abstract Cannabidiol (CBD) use has increased in America due to its widespread availability. Cannabidiol is metabolized by multiple polymorphic enzymes…
Sachiko Koyama
Cannabidiol exerts antiinflammatory effects but maintains T effector memory cell differentiation in humans
Abstract BACKGROUND: Cannabidiol (CBD) is increasingly used for pain management, including in transplant recipients with limited analgesic options. Its immunomodulatory…
Inhibition of Tacrolimus Metabolism by Cannabidiol and Its Metabolites In Vitro
Abstract Drug interactions are major causes of interindividual variability in tacrolimus exposure and effect. Tacrolimus, a widely used drug in…
Utilization of Cannabidiol in Post-Organ-Transplant Care
Abstract Cannabidiol (CBD) is one of the major phytochemical constituents of cannabis, Cannabis sativa, widely recognized for its therapeutic potential.…
A Phase I Trial of the Pharmacokinetic Interaction Between Cannabidiol and Tacrolimus
Abstract One in six Americans uses cannabidiol‐based or cannabis‐derived products. Cannabidiol is a substrate of CYP3A, but its role as…