Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds
Abstract Neurodegenerative tauopathies are caused by the transition of tau protein from a monomer to a toxic aggregate. They include…
Ping Shang
Deep learning reveals disease-specific signatures of white matter pathology in tauopathies
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-021-01271-x. Article type: Research Article Keywords: Tauopathy, Machine learning,…
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
Abstract The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome…
Comprehensive molecular characterization of mitochondrial genomes in human cancers
Abstract Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome…
Divergent mutational processes distinguish hypoxic and normoxic tumours
Abstract Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular…