Psychosis associated with cannabis withdrawal: systematic review and case series
Abstract Background: Abrupt cessation of heavy cannabis use can cause a withdrawal syndrome characterised by irritability, anxiety, insomnia, reduced appetite…
Philip McGuire
PSYSCAN multi-centre study: baseline characteristics and clinical outcomes of the clinical high risk for psychosis sample
Abstract Predicting outcomes in individuals at clinical high risk (CHR) of developing psychosis remains challenging using clinical metrics alone. The…
Novel Lipid Formulation Increases Absorption of Oral Cannabidiol (CBD)
Abstract Background: Cannabidiol (CBD) is an approved treatment for childhood epilepsies and a candidate treatment for several other CNS disorders.…
Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study
Abstract Background: The effects of cannabis are thought to be mediated by interactions between its constituents and the endocannabinoid system.…
Assessing Cannabis Use in People with Psychosis
Abstract Introduction: Cannabis use is common in people with psychotic disorders and is associated with the exacerbation of symptoms, poor…
Cannabidiol does not attenuate acute delta‐9‐tetrahydrocannabinol‐induced attentional bias in healthy volunteers: A randomised, double‐blind, cross‐over study
Abstract Aims: To test how attentional bias and explicit liking are influenced by delta‐9‐tetrahydrocannabinol (THC) and whether these effects are…
Unraveling ethnic disparities in antipsychotic prescribing among patients with psychosis: A retrospective cohort study based on electronic clinical records
Abstract Background: Previous studies have shown mixed evidence on ethnic disparities in antipsychotic prescribing among patients with psychosis in the…
Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk
Abstract Background: Preclinical and human data suggest that psychosis onset involves hippocampal glutamatergic dysfunction, driving hyperactivity and hyperperfusion in a…
Influence of cannabis use on incidence of psychosis in people at clinical high risk
Abstract Aims: Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However,…
Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios
Abstract As countries adopt more permissive cannabis policies, it is increasingly important to identify strategies that can reduce the harmful…