Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels
Abstract HCN4 channels play an important role in cardiac action potential initiation in the sinoatrial node. In this study, Page…
Peter C. Ruben
Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol
Abstract Phytocannabinoids, found in the plant, Cannabis sativa, are an important class of natural compounds with physiological effects. These compounds…
Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study
Abstract Gramicidin is a monomeric protein that is thought to non-selectively conduct cationic currents and water. Linear gramicidin is considered…
Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications
Abstract Voltage-gated sodium (Nav) channels initiate action potentials in excitable tissues. Altering these channels’ function can lead to many pathophysiological…
Protein Kinases Mediate Anti-Inflammatory Effects of Cannabidiol and Estradiol Against High Glucose in Cardiac Sodium Channels
Abstract Background: Cardiovascular anomalies are predisposing factors for diabetes-induced morbidity and mortality. Recently, we showed that high glucose induces changes…
Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity
Abstract Ghovanloo et al. combined in silico and in vitro approaches to determine the mechanism by which CBD inhibits the…
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
Abstract Cannabis sativa contains many related compounds known as phytocannabinoids. The main psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and…