UGT2B7-mediated drug–drug interaction between cannabinoids and hydromorphone
Abstract Hydromorphone is a highly potent opioid used to treat severe chronic pain. It is metabolized primarily by UDP-glucuronosyltransferase (UGT)2B7…
Mengqi Zhao
Inhibitory effects of Δ8-tetrahydrocannabinol on major hepatic cytochrome P450 enzymes and implications for drug disposition
Abstract The increased use of cannabis in many parts of the United States and other countries has led to a…
Comparative Metabolomic Profiling of the Metabolic Differences of Δ9-Tetrahydrocannabinol and Cannabidiol
Abstract More than one hundred cannabinoids have been found in cannabis. Δ9-Tetrahydrocannabinol (THC) is the recognized addictive constituent in cannabis;…
POC1A, prognostic biomarker of immunosuppressive microenvironment in cancer
Abstract POC1 centriolar protein A (POC1A) effect in pan-cancer remains uncertain. The POC1A expression in normal and tumor tissues underwent…
P4HA1, a Prognostic Biomarker that Correlates With Immune Infiltrates in Lung Adenocarcinoma and Pan-Cancer
Abstract Objective: Prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), a key enzyme in collagen synthesis, comprises two identical alpha subunits and…
Identification of Claudin-6 as a Molecular Biomarker in Pan-Cancer Through Multiple Omics Integrative Analysis
Abstract Claudin-6 (CLDN6) is one of the 27 family members of claudins and majorly involved in the tight junction and…
The role of YTH domain containing 2 in epigenetic modification and immune infiltration of pan‐cancer
Abstract YTH domain containing 2 (YTHDC2) is the largest N6‐Methyladenosine (m6A) binding protein of the YTH protein family and the…
Systematic Analysis of the Aberrances and Functional Implications of Ferroptosis in Cancer
Abstract Ferroptosis is a type of cell death related to cancer; however, the characteristics of ferroptosis in cancers are still…
Dysregulation, functional implications, and prognostic ability of the circadian clock across cancers
Abstract It has been proposed that the circadian rhythm generally plays important roles in tumor suppression, but there is also…