Dynamic aphasia as an early sign of corticobasal degeneration: Clinico-radio-pathological correlation
Abstract A 72-year-old man presented with a 6-month history of decreased voluntary speech. Sparse speech and decreased word fluency were…
Masato Hasegawa
Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study
Abstract Purpose: Due to the indistinguishable clinical features of corticobasal syndrome (CBS), the antemortem differentiation between corticobasal degeneration (CBD) and…
Pathologically Verified Corticobasal Degeneration Mimicking Richardson’s Syndrome Coexisting with Clinically and Radiologically Shunt‐Responsive Normal Pressure Hydrocephalus
Abstract Background: Normal pressure hydrocephalus (NPH) manifests as gait instability, cognitive impairment, and urinary incontinence. This clinical triad of NPH…
Human tauopathy-derived tau strains determine the substrates recruited for templated amplification
Abstract Tauopathies are a subset of neurodegenerative diseases characterized by abnormal tau inclusions. Specifically, three-repeat tau and four-repeat tau in…
Novel tau filament fold in corticobasal degeneration
Abstract Corticobasal degeneration (CBD) is a neurodegenerative tauopathy that is characterised by motor and cognitive disturbances (ref. 1–ref. 3). A…
Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain
Abstract Background: Intracytoplasmic inclusions composed of filamentous tau proteins are defining characteristics of neurodegenerative tauopathies, but it remains unclear why…