Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
Abstract Cancers harbor many somatic mutations and germline variants, we hypothesized that the combined effect of germline variants that alter…
Mark Gerstein
Comprehensive molecular characterization of mitochondrial genomes in human cancers
Abstract Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome…
Divergent mutational processes distinguish hypoxic and normoxic tumours
Abstract Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular…