The Pharmacology of Cannabinoids in Chronic Pain
Abstract Background: Our objective was to provide an overview of the currently available scientific and clinical data supporting the use…
Kent E. Vrana
Cannabinoid-Induced Immunogenic Cell Death of Colorectal Cancer Cells Through De Novo Synthesis of Ceramide Is Partially Mediated by CB2 Receptor
Abstract Mounting evidence demonstrates that cannabinoids have anti-cancer properties. The mechanism by which the cannabinoids induce cell death is still…
The Potential of Cannabichromene (CBC) as a Therapeutic Agent
Abstract SIGNIFICANCE STATEMENT: Cannabichromene (CBC) has been suggested to have disparate therapeutic benefits such as anti-inflammatory, anticonvulsant, antibacterial, and antinociceptive…
Effect of Hemp Extraction Procedures on Cannabinoid and Terpenoid Composition
Abstract A variety of techniques have been developed to extract hemp phytochemicals for research and consumption. Some of the most…
Effects of cannabidiol, with and without ∆9-tetrahydrocannabinol, on anxiety-like behavior following alcohol withdrawal in mice
Abstract Introduction: Alcohol use disorder (AUD) is commonly associated with anxiety disorders and enhanced stress-sensitivity; symptoms that can worsen during…
Systematic review of drug-drug interactions of delta-9-tetrahydrocannabinol, cannabidiol, and Cannabis
Abstract Background: The recent exponential increase in legalized medical and recreational cannabis, development of medical cannabis programs, and production of…
Cannabidiol-Derived Cannabinoids: The Unregulated Designer Drug Market Following the 2018 Farm Bill
Abstract Background: In this review, we summarize current scientific knowledge on psychoactive cannabinoids synthesized from cannabidiol (CBD) and sold in…
Antinociceptive Effects of Cannabichromene (CBC) in Mice: Insights from von Frey, Tail-Flick, Formalin, and Acetone Tests
Abstract Cannabis sativa contains minor cannabinoids that have potential therapeutic value in pain management. However, detailed experimental evidence for the…
Chronic Cannabigerol as an Effective Therapeutic for Cisplatin-Induced Neuropathic Pain
Abstract Cannabigerol (CBG), derived from the cannabis plant, acts as an acute analgesic in a model of cisplatin-induced peripheral neuropathy…
CANNabinoid Drug Interaction Review (CANN-DIR™)
Abstract Non-prescription cannabidiol (CBD) and medical marijuana (cannabis) currently do not have US Food and Drug Administration (FDA)-approved prescribing information…