Cannabidiol negatively modulates adenosine A2A receptor functioning in living cells
Abstract Objectives: Cannabidiol (CBD) is a phytocannabinoid with great potential in clinical applications. The mechanism(s) of action of CBD require…
Kenneth A. Jacobson
Terpenes from Cannabis sativa Induce Antinociception in Mouse Chronic Neuropathic Pain via Activation of Spinal Cord Adenosine A2A Receptors
Abstract Terpenes are small hydrocarbon compounds that impart aroma and taste to many plants, including Cannabis sativa. A number of…
Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs
Abstract Many ligands directly target adenosine receptors (ARs). Here we review the effects of noncanonical AR drugs on adenosinergic signaling.…