Jiashan Zhang

January 6, 2022

MiR-30c-5p loss-induced PELI1 accumulation regulates cell proliferation and migration via activating PI3K/AKT pathway in papillary thyroid carcinoma

Abstract Background: The aberrant expression of E3 ubiquitin ligase Pellino-1 (PELI1) contributes to several human cancer development and progression. However,…

September 21, 2020

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Abstract The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome…

February 5, 2020

Divergent mutational processes distinguish hypoxic and normoxic tumours

Abstract Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular…

February 5, 2020

Comprehensive molecular characterization of mitochondrial genomes in human cancers

Abstract Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome…