Comprehensive analysis of BIRC5: from pan-cancer analysis to experimental validation
Abstract Background: Baculoviral inhibitor of apoptosis protein repeat-containing protein 5 (BIRC5), also known as survivin, belongs to the inhibitor of…
Jianzhang Yang
Defining CDK12 as a tumor suppressor and therapeutic target in mouse models of tubo-ovarian high-grade serous carcinoma
Abstract Using novel mouse models, we establish cyclin-dependent kinase 12 (CDK12) as a bona fide tumor suppressor gene in tubo-ovarian…