Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways
Abstract The RNA exosome is a versatile ribonuclease. In the nucleoplasm of mammalian cells, it is assisted by its adaptors…
Jens S. Andersen
The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype
Abstract Oncogene-induced senescence provides a barrier against malignant transformation. However, it can also promote cancer through the secretion of a…
Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions
Abstract Nuclear RNA metabolism is influenced by protein complexes connecting to both RNA-productive and -destructive pathways. The ZC3H18 protein binds…
Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate
Abstract The nuclear cap-binding complex (CBC) stimulates processing reactions of capped RNAs, including their splicing, 3′-end formation, degradation, and transport.…
The human cap-binding complex is functionally connected to the nuclear RNA exosome
Abstract Nuclear processing and quality control of eukaryotic RNA is mediated by the RNA exosome, which is regulated by accessory…