Cannabinoids and opioid consumption in cancer pain: a systematic review and meta-analysis
Abstract Background: Opioids are the mainstay of cancer-related pain management but are limited by adverse effects and clinical complexity. Cannabinoids…
Ioana Creangă-Murariu
Antitumor Activity of Cannabinoids and Their Interaction with Chemotherapy: A Systematic Review and Meta-Analysis of Preclinical Evidence
Abstract Background: Cannabinoids are studied as anticancer agents, but their effects vary across tumors, compounds, and experimental settings, underscoring the…
MRI-Based Radiomics Reveals Cannabinoid-Associated Tumor Phenotypes in a Murine Breast Cancer Model
Abstract Introduction and Aim: Assessment of antitumor activity in preclinical models remains challenging when relying solely on conventional size-based imaging,…
Multifaced roles of cannabinoid therapy in cancer: balancing analgesia, antitumor potential, and systemic toxicity
Abstract Introduction: Cannabinoids hold promise in oncology for symptom relief and antitumor effects, though concerns about safety and efficacy persist.…
Indications of Cannabinoids for the Palliation of Cancer-Associated Symptoms: A Systematic Review and Meta-Analysis
Abstract Purpose of the Review: As cancer survival rates are increasing, alternative treatments to improve quality of life, such as…
JWH-182: a safe and effective synthetic cannabinoid for chemotherapy-induced neuropathic pain in preclinical models
Abstract Chemotherapy-induced neuropathic pain (CINP), a condition with unmet treatment needs, affects over half of cancer patients treated with chemotherapeutics.…
The potential neuroprotective effects of cannabinoids against paclitaxel-induced peripheral neuropathy: in vitro study on neurite outgrowth
Abstract Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a shared burden for 68.1% of oncological patients undergoing chemotherapy with Paclitaxel (PTX).…
Should oncologists trust cannabinoids?
Abstract Cannabis enjoyed a “golden age” as a medicinal product in the late 19th, early 20th century, but the increased…
Acute Toxicity and Pharmacokinetic Profile of an EU-GMP-Certified Cannabis sativa L. in Rodents
Abstract The conundrum of Cannabis sativa’s applications for therapeutical purposes is set apart by the hundreds of known and commercially…
The Therapeutic Potential of the Endocannabinoid System in Age-Related Diseases
Abstract The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian physiology. ECS has gained substantial interest since growing evidence…