Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice
Abstract Aging is associated with cognitive decline, and currently, there are no approved medications that can prevent these impairments. Recently,…
Igor Kovalchuk
The Impact of Major and Minor Phytocannabinoids on the Maintenance and Function of INS-1 β-Cells Under High-Glucose and High-Lipid Conditions
Abstract Type 2 diabetes mellites (T2DM) is the most common form of diabetes and affects a significant portion of the…
Entomopathogenic Fungi Effectively Control Phorodon cannabis Aphid Population in Cannabis sativa Plants
Abstract The rapid expansion of the cannabis industry in Canada post-legalization has heightened the prevalence of pests, particularly the cannabis…
Targeting carbohydrate metabolism in colorectal cancer – synergy between DNA-damaging agents, cannabinoids, and intermittent serum starvation
Abstract Chemotherapy is a therapy of choice for many cancers. However, it is often inefficient for long-term patient survival and…
Targeting Colorectal Cancer: Unravelling the Transcriptomic Impact of Cisplatin and High-THC Cannabis Extract
Abstract Cisplatin and other platinum-derived chemotherapy drugs have been used for the treatment of cancer for a long time and…
Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells
Abstract Platinum-derived chemotherapy medications are often combined with other conventional therapies for treating different tumors, including colorectal cancer. However, the…
Anti-Inflammatory Effects of Minor Cannabinoids CBC, THCV, and CBN in Human Macrophages
Abstract Inflammation is a natural response of the body to signals of tissue damage or infection caused by pathogens. However,…
High-CBD cannabis extracts inhibit the expression of proinflammatory factors via miRNA-mediated silencing in human small intestinal epithelial cells
Abstract The incidence of chronic inflammatory disorders and autoimmune diseases is rapidly growing. To date, the COVID-19 pandemic caused by…
The Anti-Inflammatory Effects of Cannabis sativa Extracts on LPS-Induced Cytokines Release in Human Macrophages
Abstract Inflammation is the response of the innate immune system to any type of injury. Although acute inflammation is critical…
Phytocannabinoids Stimulate Rejuvenation and Prevent Cellular Senescence in Human Dermal Fibroblasts
Abstract In light of the increased popularity of phytocannabinoids (pCBs) and their appearance in beauty products without rigorous research on…