Use of Cannabis and Cannabinoids for Treatment of Cancer
Abstract Simple Summary: Cancer is a disease which affects approximately 40% of people in their lifetime. Chemotherapy, the primary choice…
Igor Kovalchuk
Analysis of Anti-Cancer and Anti-Inflammatory Properties of 25 High-THC Cannabis Extracts
Abstract Cannabis sativa is one of the oldest cultivated plants. Many of the medicinal properties of cannabis are known, although…
The Effects of Nutrient Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Phenotype in Human Dermal Fibroblasts
Abstract Identifying effective anti-aging compounds is a cornerstone of modern longevity, aging, and skin-health research. There is considerable evidence of…
Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signaling and TYK2-Mediated STAT3 Signaling Pathways In Vitro
Abstract Cannabinoids, mainly cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), are the most studied group of compounds obtained from Cannabis sativa because…
Cannabinol Inhibits Cellular Proliferation, Invasion, and Angiogenesis of Neuroblastoma via Novel miR-34a/tRiMetF31/PFKFB3 Axis
Abstract Simple Summary: The prognosis of high-risk neuroblastoma is poor due to its high relapse rate. To date, no effective…
Medical Cannabis in Pediatric Oncology: Friend or Foe?
Abstract The antineoplastic effects of cannabis have been known since 1975. Since the identification of the components of the endogenous…
New AKT-dependent mechanisms of anti-COVID-19 action of high-CBD Cannabis sativa extracts
Abstract COVID-19 is caused by the SARS-CoV-2 virus, which enters target cells via interactions with ACE2 and TMPRSS2. Here, we…
The Potential Use of Cannabis in Tissue Fibrosis
Abstract Fibrosis is a condition characterized by thickening or/and scarring of various tissues. Fibrosis may develop in almost all tissues…
Cannabinoids, Medical Cannabis, and Colorectal Cancer Immunotherapy
Abstract Colorectal cancer is a major public health problem. Unfortunately, currently, no effective curative option exists for this type of…
Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer
Abstract Simple Summary: In recent years, multiple preclinical studies have shown that changes in endocannabinoid system signaling may have various…