The potential role of cuproptosis-related genes for therapy and immunoregulation in pan-cancer
Abstract The primary drawbacks of current cancer therapies are lower selectivity for cancer cells, more side effects, and obscure resistance…
Hongjia Liu
Pan-Cancer Analysis Reveals the Potential of PLOD1 as a Prognostic and Immune Biomarker for Human Cancer
Abstract Background/Objectives: Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1) is known as an enhancer of collagen fiber deposition and cross-linking stability. However,…
Integrated Analysis of Clinical Outcome of Mesenchymal Stem Cell-related Genes in Pan-cancer
Abstract Background: Although the application of mesenchymal stem cells (MSCs) in engineered medicine, such as tissue regeneration, is well known,…
Aberrant RBMX expression is relevant for cancer prognosis and immunotherapy response
Abstract Cancer accounts for the highest rates of morbidity and mortality worldwide. RNA binding motif protein X-linked (RBMX) is a…
How to implement minimally invasive duodenum-preserving total pancreatic head resection for patients with pancreatic head lesions: A retrospective study
Abstract Laparoscopic duodenum-preserving pancreatic head resection (LDPPHR) has been widely reported. However, due to the challenges involved in performing total…
Identifying and characterizing lincRNA genomic clusters reveals its cooperative functions in human cancer
Abstract Background: Emerging evidence has revealed that some long intergenic non-coding RNAs (lincRNAs) are likely to form clusters on the…
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
Abstract The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome…
Neuroprotective constituents from the aerial parts of Cannabis sativa L. subsp. sativa†
Abstract Five new compounds including three new cannabinoids, cannabisativas A–C (1–3), two new phenolic acids, (7Z,9Z)-cannabiphenolic acid A (4) and…
Comprehensive molecular characterization of mitochondrial genomes in human cancers
Abstract Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome…
Divergent mutational processes distinguish hypoxic and normoxic tumours
Abstract Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular…