Comprehensive analysis of BIRC5: from pan-cancer analysis to experimental validation
Abstract Background: Baculoviral inhibitor of apoptosis protein repeat-containing protein 5 (BIRC5), also known as survivin, belongs to the inhibitor of…
Guoqing Liu
Pan-cancer analysis reveals ASCC family promotes the cancer progression of lung adenocarcinoma
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-03946-0. Article type: Research Article Keywords: ASCC1/2/3, ASC-1 complex,…
The pan-cancer landscape of aldo-keto reductase1B10 reveals that its expression is diminished in gastric cancer
Abstract Introduction: Aldo-keto reductase 1B10 (AKR1B10) is a multifunctional enzyme, which is important in cancer development and progression, but the…
Cyclin B1: A potential prognostic and immunological biomarker in pan-cancer
Abstract Cyclin B1 (CCNB1) encodes a regulatory protein essential for the regulation of cell mitosis, particularly in controlling the G2/M…
Deciphering the molecular and clinical characteristics of TREM2, HCST, and TYROBP in cancer immunity: A comprehensive pan-cancer study
Abstract Background: Hematopoietic cell signal transducer (HCST) and tyrosine kinase-binding protein (TYROBP) are triggering receptors expressed on myeloid cells 2…
Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer
Abstract Objective: To investigate the prognostic significance of optic atrophy 1 (OPA1) in pan-cancer and analyze the relationship between OPA1…
Development of a thyroid cancer prognostic model based on the mitophagy-associated differentially expressed genes
Abstract Background: The prevalence of thyroid cancer (ThyC), a frequent malignant tumor of the endocrine system, has been rapidly increasing…
A pan-cancer analysis of lipid metabolic alterations in primary and metastatic cancers
Abstract Metabolic reprogramming is a hallmark of cancers, but pan-cancer level roles of lipid metabolism in cancer development are remains…
Integrative transcriptome analysis identifies MYBL2 as a poor prognosis marker for osteosarcoma and a pan-cancer marker of immune infiltration
Abstract MYBL2 (MYB proto-oncogene like 2) is an emerging prognostic marker for malignant tumors, and its potential role in osteosarcoma…
Pan‐cancer analyses reveal molecular and clinical characteristics of cuproptosis regulators
Abstract Imbalance in copper homeostasis can be lethal. A recent study found that excess copper induces cell death in a…