Abstract Cannabis is the most widely used illicit drug, particularly during adolescence. Its consumption disrupts glutamate homeostasis and synaptic plasticity…
Abstract Growth-associated protein of 43 kDa (GAP43) is a key cytoskeleton-associated component of the presynaptic terminal that facilitates neuroplasticity. Downregulation…
Abstract Mutations in mitochondrial energy-producing genes lead to a heterogeneous group of untreatable disorders known as primary mitochondrial diseases (MD).…
Abstract Astrocytes control brain activity via both metabolic processes and gliotransmission, but the physiological links between these functions are scantly…
Abstract Cannabis use disorder (CUD) is widespread, and there is no pharmacotherapy to facilitate its treatment. AEF0117, the first of…
Abstract The type-1 cannabinoid receptor (CB1R) is widely expressed in excitatory and inhibitory nerve terminals, and by suppressing neurotransmitter release,…
Abstract Rationale: The use of synthetic cannabinoid receptor agonists (SCRAs) is growing among adolescents, posing major medical and psychiatric risks.…
Abstract The study of the astrocytic contribution to brain functions has been growing in popularity in the neuroscience field. In…
Abstract Cannabinoids, the bioactive constituents of cannabis, exert a wide array of effects on the brain by engaging Type 1…
Abstract The use of cannabis is rapidly expanding worldwide. Thus, innovative studies aimed to identify, understand and potentially reduce cannabis-evoked…