Are CB2 Receptors a New Target for Schizophrenia Treatment?
Abstract Schizophrenia is a complex disorder that involves several neurotransmitters such as dopamine, glutamate, and GABA. More recently, the endocannabinoid…
Francisco S. Guimarães
Biological bases for a possible effect of cannabidiol in Parkinson’s disease
Abstract Current pharmacotherapy of Parkinson’s disease (PD) is palliative and unable to modify the progression of neurodegeneration. Treatments that can…
Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test
Abstract Objective: Cannabidiol (CBD), one of the non-psychotomimetic compounds of Cannabis sativa, causes anxiolytic-like effects in animals, with typical bell-shaped…
Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
Abstract Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the…
No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
Abstract Cannabidiol (CBD) is a component of Cannabis sativa that has a broad spectrum of potential therapeutic effects in neuropsychiatric…
Cannabinoid Modulation of the Stressed Hippocampus
Abstract Exposure to stressful situations is one of the risk factors for the precipitation of several psychiatric disorders, including Major…
Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders
Abstract Beneficial effects of cannabidiol (CBD) have been described for a wide range of psychiatric disorders, including anxiety, psychosis, and…
Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life
Abstract The purpose of this study was to investigate whether the anxiolytic effect of cannabidiol (CBD) in humans follows the…
Bidirectional Effects of Cannabidiol on Contextual Fear Memory Extinction
Abstract Cannabidiol (CBD) has been established to have both acute and long-lasting effects to reduce fear memory expression. The long-lasting…
Cannabidiol Regulation of Learned Fear: Implications for Treating Anxiety-Related Disorders
Abstract Anxiety and trauma-related disorders are psychiatric diseases with a lifetime prevalence of up to 25%. Phobias and post-traumatic stress…