Unveiling cellular changes in leukaemia cell lines after cannabidiol treatment through lipidomics
Abstract The present study was aimed at revealing the metabolic changes that occurred in the cellular lipid pattern of acute…
Federica Pellati
A new HPLC method with multiple detection systems for impurity analysis and discrimination of natural versus synthetic cannabidiol
Abstract Graphical Abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s00216-024-05396-5. Article type: Research Article Keywords: Cannabidiol,…
Extraction, purification and in vitro assessment of the antioxidant and anti-inflammatory activity of policosanols from non-psychoactive Cannabis sativa L.
Abstract Policosanols (PCs) are bioactive compounds extracted from different natural waxes. In this work, the purification, characterization and assessment of…
A label free chemoproteomic-based platform to disclose cannabidiol molecular mechanism of action on chronic myelogenous leukemia cancer cells
Abstract The discovery of the interactome of cannabidiol (CBD), a non-psychoactive cannabinoid from Cannabis sativa L., has been here performed…
Non‐psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors‐, endocannabinoids‐, and NF‐κB‐mediated signaling
Abstract Cannabis sativa L. is increasingly emerging for its protective role in modulating neuroinflammation, a complex process orchestrated among others…
Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography
Abstract This work reports about a screening of four adsorbents with different polarity employed for the separation of the main…
Chemical characterization of non‐psychoactive Cannabis sativa L. extracts, in vitro antiproliferative activity and induction of apoptosis in chronic myelogenous leukaemia cancer cells
Abstract In this study, extracts from non‐psychoactive Cannabis sativa L. varieties were characterized by means of ultra high‐performance liquid chromatography…
Antiseizure Effects of Fully Characterized Non-Psychoactive Cannabis sativa L. Extracts in the Repeated 6-Hz Corneal Stimulation Test
Abstract Compounds present in Cannabis sativa L. preparations have recently attracted much attention in the treatment of drug-resistant epilepsy. Here,…
In Silico Repositioning of Cannabigerol as a Novel Inhibitor of the Enoyl Acyl Carrier Protein (ACP) Reductase (InhA)
Abstract Cannabigerol (CBG) and cannabichromene (CBC) are non-psychoactive cannabinoids that have raised increasing interest in recent years. These compounds exhibit…
Chemical Characterization and Evaluation of the Antibacterial Activity of Essential Oils from Fibre-Type Cannabis sativa L. (Hemp)
Abstract Volatile terpenes represent the largest group of Cannabis sativa L. components and they are responsible for its aromatic properties.…