Phytocannabinoids in the Pharmacotherapy of Psoriasis
Abstract Phytocannabinoids are naturally occurring compounds, the main source of which is Cannabis sativa L. Through direct action or interaction…
Elżbieta Skrzydlewska
The molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NF-κB pathway under oxidative stress
Abstract Cannabidiol (CBD), the major non-psychoactive phytocannabinoid of Cannabis sativa L., is one of the most studied compounds in pharmacotherapeutic…
The Origin and Biomedical Relevance of Cannabigerol
Abstract The constant search for new pharmacologically active compounds, especially those that do not exhibit toxic effects, intensifies the interest…
Influence of Inhibition of COX-2-Dependent Lipid Metabolism on Regulation of UVB-Induced Keratinocytes Apoptosis by Cannabinoids
Abstract Inflammation and apoptosis are regulated by similar factors, including ultraviolet B (UVB) radiation and cannabinoids, which are metabolized by…
UV induced changes in proteome of rats plasma are reversed by dermally applied cannabidiol
Abstract UV radiation is known to induce a multiple changes in the metabolism of skin-building cells, what can affect the…
Cannabidiol Decreases Metalloproteinase Activity and Normalizes Angiogenesis Factor Expression in UVB-Irradiated Keratinocytes from Psoriatic Patients
Abstract The development of psoriasis is associated with the consequences of oxidative stress and inflammation leading to metabolic changes locally,…
Disease-Dependent Antiapoptotic Effects of Cannabidiol for Keratinocytes Observed upon UV Irradiation
Abstract Although apoptosis of keratinocytes has been relatively well studied, there is a lack of information comparing potentially proapoptotic treatments…
Changes in Phospholipid/Ceramide Profiles and Eicosanoid Levels in the Plasma of Rats Irradiated with UV Rays and Treated Topically with Cannabidiol
Abstract Chronic UV radiation causes oxidative stress and inflammation of skin and blood cells. Therefore, in this study, we assessed…
Changes in Hepatic Phospholipid Metabolism in Rats under UV Irradiation and Topically Treated with Cannabidiol
Abstract The liver is a key metabolic organ that is particularly sensitive to environmental factors, including UV radiation. As UV…
Protective effects of cannabidiol on the membrane proteins of skin keratinocytes exposed to hydrogen peroxide via participation in the proteostasis network
Abstract Hydrogen peroxide (H2O2) is widely used in clinical practice due to its antiseptic properties and its ability to heal…