The Effect of Cannabidiol on UV-Induced Changes in Intracellular Signaling of 3D-Cultured Skin Keratinocytes
Abstract Human epidermal keratinocytes are constantly exposed to UV radiation. As a result, there is a significant need for safe…
Elżbieta Skrzydlewska
Oxidative Stress and Lipid Mediators Modulate Immune Cell Functions in Autoimmune Diseases
Abstract Autoimmune diseases, including psoriasis, systemic lupus erythematosus (SLE), and rheumatic arthritis (RA), are caused by a combination of environmental…
Changes in Lipid Profile of Keratinocytes from Rat Skin Exposed to Chronic UVA or UVB Radiation and Topical Application of Cannabidiol
Abstract UV radiation is a well-established environmental risk factor known to cause oxidative stress and disrupt the metabolism of keratinocyte…
Cannabidiol Modifies the Formation of NETs in Neutrophils of Psoriatic Patients
Abstract Psoriasis is associated with increased production of reactive oxygen species which leads to oxidative stress. As antioxidants can provide…
Cannabidiol-Mediated Changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic Patients
Abstract UVB phototherapy is treatment for psoriasis, which increases phospholipid oxidative modifications in the cell membrane of the skin. Therefore,…
Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis
Abstract Apoptosis is the physiological mechanism of cell death and can be modulated by endogenous and exogenous factors, including stress…
Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris
Abstract Psoriasis is a chronic inflammatory skin disease characterized by dysregulated keratinocyte differentiation, but oxidative stress also plays an important…
Antioxidative and Anti-Inflammatory Properties of Cannabidiol
Abstract Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids of Cannabis sativa L. CBD is non-psychoactive but exerts…
The Differences in the Proteome Profile of Cannabidiol-Treated Skin Fibroblasts following UVA or UVB Irradiation in 2D and 3D Cell Cultures
Abstract Cannabidiol (CBD), as the only phytocannabinoid that has no psychoactive effect, has both antioxidant and anti-inflammatory effects, and thus…
Cannabidiol Regulates the Expression of Keratinocyte Proteins Involved in the Inflammation Process through Transcriptional Regulation
Abstract Cannabidiol (CBD), a natural phytocannabinoid without psychoactive effect, is a well-known anti-inflammatory and antioxidant compound. The possibility of its…