Cannabinoids and opioid consumption in cancer pain: a systematic review and meta-analysis
Abstract Background: Opioids are the mainstay of cancer-related pain management but are limited by adverse effects and clinical complexity. Cannabinoids…
Bogdan-Ionel Tamba
Navigating dose-effect complexities and challenges in cannabinoid therapy for aging-related neurobiological changes
Abstract Growing evidence shows that brain aging is a time-dependent process, with very complex underlying mechanisms at molecular and cellular…
Antitumor Activity of Cannabinoids and Their Interaction with Chemotherapy: A Systematic Review and Meta-Analysis of Preclinical Evidence
Abstract Background: Cannabinoids are studied as anticancer agents, but their effects vary across tumors, compounds, and experimental settings, underscoring the…
MRI-Based Radiomics Reveals Cannabinoid-Associated Tumor Phenotypes in a Murine Breast Cancer Model
Abstract Introduction and Aim: Assessment of antitumor activity in preclinical models remains challenging when relying solely on conventional size-based imaging,…
Therapeutic relevance of an EU-GMP certified Cannabis sativa L. strain in a dual in vivo model of cognitive impairment and chronic neuropathic pain
Abstract Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and frequently co-occurs with chronic pain.…
Evaluation of long-term safety profile of an EU-GMP certified Cannabis sativa L. strain in a naturally aging preclinical model
Abstract Aging is characterized in part by chronic, low-grade inflammation, a major driver of cognitive decline, metabolic imbalance and organ…
Multifaced roles of cannabinoid therapy in cancer: balancing analgesia, antitumor potential, and systemic toxicity
Abstract Introduction: Cannabinoids hold promise in oncology for symptom relief and antitumor effects, though concerns about safety and efficacy persist.…
Exploring the impact of chronic intermittent EU-GMP certified Cannabis sativa L. therapy and its relevance in a rat model of aging
Abstract Background: Aging is a multifaceted process marked by the progressive accumulation of cellular damage in various tissues, resulting in…
Indications of Cannabinoids for the Palliation of Cancer-Associated Symptoms: A Systematic Review and Meta-Analysis
Abstract Purpose of the Review: As cancer survival rates are increasing, alternative treatments to improve quality of life, such as…
Exploring novel therapeutic strategies: Could psychedelic perspectives offer promising solutions for Alzheimer’s disease comorbidities?
Abstract The increasing prevalence of dementia within an ageing global population, combined with prolonged life expectancy, accentuates Alzheimer’s disease (AD)…