Down-regulation of interleukin-2 predicts poor prognosis and associated with immune escape in lung adenocarcinoma
Abstract Background and Objective: Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer and has a poor prognosis.…
Bin Zhang
Role of Hub Genes in the Occurrence and Development of Testicular Cancer Based on Bioinformatics
Abstract Background: Testicular cancer severely affects male health, so finding effective diagnosis and prognostic indicators and exploring its pathogenesis are…
Prognostic and immunological role of Fam20C in pan-cancer
Abstract Background: The family with sequence similarity 20-member C (Fam20C) kinase plays important roles in physiopathological process and is responsible…
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00401-020-02253-4. Article type: Research Article Keywords: tauopathy, tau spreading,…
Human tau pathology transmits glial tau aggregates in the absence of neuronal tau
Abstract The pathogenesis of glial tau pathology is unknown. This study shows glial tau pathology can propagate in the absence…
A comprehensive expression landscape of RNA-binding proteins (RBPs) across 16 human cancer types
Abstract RNA-binding proteins (RBPs) are key regulators of posttranscriptional processes such as RNA maturation, localization, turnover and translation. Despite their…
Tetrahydrocurcumin Ameliorates Diabetic Cardiomyopathy by Attenuating High Glucose-Induced Oxidative Stress and Fibrosis via Activating the SIRT1 Pathway
Abstract Hyperglycemia-induced oxidative stress and fibrosis play a crucial role in the development of diabetic cardiomyopathy (DCM). Tetrahydrocurcumin (THC), a…