Human tau pathology transmits glial tau aggregates in the absence of neuronal tau

Abstract The pathogenesis of glial tau pathology is unknown. This study shows glial tau pathology can propagate in the absence of neuronal tau. In particular, oligodendrocytes transmit tau pathology via their own processes, independent of neuronal tau. Authors: Sneha Narasimhan ⚬, Lakshmi Changolkar, Dawn M. Riddle, Alexandra Kats, Anna Stieber, Sarah A. Weitzman, Bin Zhang ⚬, Zhiyong Li, Erik D. Roberson ⚬, John Q. Trojanowski ⚬, Virginia M.Y. Lee ⚬ Affiliations: Department of Pathology and Laboratory Medicine, Institute on Aging