Cannabis use and psychotic-like experiences in the All of Us Research Program
Abstract Background and Hypothesis: Cannabis use has been linked to psychotic-like experiences (PLEs). Amid increasing legalization, we examined the extent…
Arpana Agrawal
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
Abstract As recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing…
Prenatal cannabis exposure is associated with localized brain differences that partially mediate associations with increased adolescent psychopathology
Abstract Prenatal cannabis exposure (PCE) is associated with mental health problems, but the neurobiological mechanisms remain unknown. We find that…
Associations Between Cannabis Use, Polygenic Liability for Schizophrenia, and Cannabis-related Experiences in a Sample of Cannabis Users
Abstract Background and Hypothesis: Risk for cannabis use and schizophrenia is influenced in part by genetic factors, and there is…
A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans
Abstract Cannabis, the most widely used illicit drug, can induce hallucinations. Our understanding of the biology of cannabis-induced hallucinations (Ca-HL)…
Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Abstract Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic…
Genomewide association study identifies a novel locus for cannabis dependence
Abstract Despite moderate heritability, only one study has identified genomewide significant loci for cannabis-related phenotypes. We conducted meta-analyses of genomewide…