Organelle contact sites in cancer cells
Abstract Membrane contact sites (MCSs) are defined as regions of functional proximity between membranes belonging to the same or different…
Review Article
Cannabis use among cancer survivors: a systematic review and meta-analysis
Abstract Introduction: The use of medical cannabis has been receiving growing attention as a potential therapeutic option for a diverse…
Cannabis Use Disorder in the Era of Legalization: Implications for Addiction Treatment Systems
Abstract Introduction: Cannabis legalization has expanded rapidly across high-income jurisdictions, altering patterns of cannabis use, product potency, and commercial markets.…
Mechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review
Abstract Insomnia is increasingly recognized as a manifestation of multisystem dysregulation characterized by sustained physiological hyperarousal. This review situates insomnia…
Game Changers in the Treatment of and Engagement With Persons Living With Mental Health and Substance Use Disorders: The Role of the Nurse
Abstract The game changers in mental health and substance use disorder treatment have been shaped by historical sea changes marked…
Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment
Abstract Chronic pain is a globally prevalent and complex condition, encompassing three primary subtypes, that is, nociceptive, neuropathic, and nociplastic,…
Plant-Derived Functional Ingredients in Pet Nutrition: Phytochemical Classification, Mechanisms, Efficacy, and Application in Dogs and Cats
Abstract Modern pet nutrition is evolving toward the use of phytochemical-rich, plant-derived ingredients that provide health benefits rather than basic…
Natural Product-Derived Activity-Based and Affinity-Based Probes: Tools for Mechanism of Action Studies
Abstract Natural products have played a pivotal role in the history of drug discovery, yet mechanistic investigations have often posed…
Cannabidiol in Developmental Epilepsy: Organoid-Guided Precision Medicine Across Critical Neurodevelopmental Windows
Abstract Epilepsy is a progressive network disorder in which recurrent seizures drive maladaptive neurodevelopmental remodeling, cognitive decline, and pharmacoresistance, particularly…
The Therapeutic Crossroad Between Mitochondria and Cannabidiol: A Mini-Review
Abstract Cannabidiol is a compound from the plant Cannabis sativa that does not produce psychoactive effects and has increasingly been…