Enhancing Cannabinoid Bioavailability in Pain Management: The Role of Cyclodextrins
Abstract Chronic pain (CP), including pain related to cancer, affects approximately 2 billion people worldwide, significantly diminishing quality of life…
Review Article
Targeting carbohydrate metabolism in colorectal cancer – synergy between DNA-damaging agents, cannabinoids, and intermittent serum starvation
Abstract Chemotherapy is a therapy of choice for many cancers. However, it is often inefficient for long-term patient survival and…
Harnessing the healing power of nature: a review of natural interventions in substance abuse treatment and prevention
Abstract Background: Substance abuse is a global problem that cuts across all sectors of society and requires innovative solutions that…
Antioxidant Potential of Medicinal Plants in the Treatment of Scabies Infestation
Abstract Oxidative stress, characterized by an overproduction of reactive oxygen species that overwhelm the body’s physiological defense mechanisms, is a…
New Insights into the Development of Donepezil-Based Hybrid and Natural Molecules as Multi-Target Drug Agents for Alzheimer’s Disease Treatment
Abstract Alzheimer’s disease (AD) involves a complex pathophysiology with multiple interconnected subpathologies, including protein aggregation, impaired neurotransmission, oxidative stress, and…
A Review of Sturge–Weber Syndrome Brain Involvement, Cannabidiol Treatment and Molecular Pathways
Abstract Sturge–Weber syndrome (SWS) is a rare congenital neurocutaneous disorder typically caused by a somatic mosaic mutation in R183Q GNAQ.…
Profile of Trofinetide in the Treatment of Rett Syndrome: Design, Development and Potential Place in Therapy
Abstract Trofinetide is a first-in-class pharmacological treatment proposed for patients with Rett Syndrome. It is a long half-life derivative of…
Arrhythmias and cannabis use: A comprehensive overview
Abstract The increasing prevalence of cannabis use, with an estimated 219 million users globally, underscores the need to examine its…
Cannabinoids and General Anesthetics: Revisiting Molecular Mechanisms of Their Pharmacological Interactions
Abstract Cannabis has been used for recreation and medical purposes for more than a millennium across the world; however, its…
Endocannabinoid System and Metabolism: The Influences of Sex
Abstract The endocannabinoid system (ECS) is a lipid signaling system involved in numerous physiological processes, such as endocrine homeostasis, appetite…