Cannabinoids in Chronic Pain: Clinical Outcomes, Adverse Effects and Legal Challenges
Abstract Cannabinoids have gained increasing attention as potential therapeutic agents in chronic pain management. Their mechanisms of action, mediated through…
Review Article
Progress in genetic mechanisms and precise treatment of neurocutaneous syndrome-related epilepsy
Abstract Neurocutaneous syndromes are a group of genetic disorders involving the nervous and cutaneous systems, including Tuberous Sclerosis Complex (TSC),…
A Meta-Narrative Review of Channelopathies and Cannabis: Mechanistic, Epidemiologic, and Forensic Insights into Arrhythmia and Sudden Cardiac Death
Abstract Although cannabinoids have proven therapeutic benefits, they are increasingly known for their capacity to disturb cardiac electrophysiology, particularly in…
Practical approach to the safe use of cannabidiol in patients with refractory epilepsy: a mini review
Abstract Drug-resistant epilepsy (DRE), characterized by seizures that are unresponsive to the use of two or more conventional anti-seizure medication…
Cannabis use in adolescence and young adulthood and its effects on brain structure and function: a scoping review
Abstract Introduction: Adolescence and young adulthood are simultaneously periods of significant brain development and the ages in which people often…
A systematic review of protein post-translational modifications in sepsis
Abstract Background: Sepsis originates from the host’s dysregulated response to pathogens, and its pathophysiological mechanisms are extremely complex. Recent research…
Genetic and Mechanistic Insights Inform Amyotrophic Lateral Sclerosis Treatment and Symptomatic Management: Current and Emerging Therapeutics and Clinical Trial Design Considerations
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting both upper and lower motor neurons. ALS is classically…
Management and Prevention of Neurodegenerative Disorders: Can Antioxidant-Rich Dietary Interventions Help?
Abstract Neurodegenerative diseases are associated with the senescence of functional neurons, which hampers brain functions. These diseases are caused by…
Vaping and Smoking in Pregnancy—A Meta‐Analysis of Neurobehavioural Development in Prenatally Exposed Offspring
Abstract Aim: Electronic cigarette usage has become increasingly popular in recent years, advertised as a safe alternative to smoking. However,…
Pharmacological mechanism of natural antidepressants: the role of epigenetic modifications
Abstract MDD is a complex mental illness shaped by the interplay between genetic vulnerability and environmental triggers. Its underlying pathophysiological…