Genes and signaling pathways involved in memory enhancement in mutant mice
Abstract Mutant mice have been used successfully as a tool for investigating the mechanisms of memory at multiple levels, from…
Review Article
Gone to Pot – A Review of the Association between Cannabis and Psychosis
Abstract Cannabis is the most commonly used illicit drug worldwide, with ~5 million daily users worldwide. Emerging evidence supports a…
Endocannabinoids are Involved in Male Vertebrate Reproduction: Regulatory Mechanisms at Central and Gonadal Level
Abstract Endocannabinoids (eCBs) are natural lipids regulating a large array of physiological functions and behaviors in vertebrates. The eCB system…
The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain
Abstract In response to physiological and psychogenic stressors, the hypothalamic–pituitary–adrenal (HPA) axis orchestrates the systemic release of glucocorticoids (GCs). By…
Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
Abstract The limited effectiveness of current therapies against Alzheimer’s disease (AD) highlights the need for intensifying research efforts devoted to…
Use of Natural Compounds in the Management of Diabetic Peripheral Neuropathy
Abstract Nephropathy, retinopathy cardiomyopathy and peripheral neuropathy are all recognized as important complications in about 50% of diabetes mellitus (DM)…
Pancreatic cancer cachexia: a review of mechanisms and therapeutics
Abstract Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately,…
Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression
Abstract Herein we evaluate the involvement of the TRPV2 channel, belonging to the Transient Receptor Potential Vanilloid channel family (TRPVs),…
Review of pharmacological therapies in fibromyalgia syndrome
Abstract This review addresses the current status of drug therapy for the management of fibromyalgia syndrome (FMS) and is based…
The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia
Abstract The endocannabinoid system is widespread throughout the central nervous system and its type 1 receptor (CB1) plays a crucial…