Neuropsychological Consequences of Chronic Drug Use: Relevance to Treatment Approaches
Abstract Heavy use of drugs impacts of the daily activities of individuals in these activities. Several groups of investigators have…
Review Article
Tackling the Pharmaceutical Frontier: Regulation of Cannabinoid-Based Medicines in Postwar Japan
Abstract Background: The valley of death, which refers to the gap due to the lack of support for the translation…
Allosteric Modulators of the CB1 Cannabinoid Receptor: A Structural Update Review
Abstract In 2005, the first evidence of an allosteric binding site at the CB1R was provided by the identification of…
Cellular Mechanisms of Action of Drug Abuse on Olfactory Neurons
Abstract Cannabinoids (Δ9-tetrahydrocannabinol) are the active ingredient of marijuana (cannabis) which is the most commonly abused illicit drug in the…
To Act or Not to Act: Endocannabinoid/Dopamine Interactions in Decision-Making
Abstract Decision-making is an ethologically adaptive construct that is impaired in multiple psychiatric disorders. Activity within the mesocorticolimbic dopamine system…
Oxyradical Stress, Endocannabinoids, and Atherosclerosis
Abstract Atherosclerosis is responsible for most cardiovascular disease (CVD) and is caused by several factors including hypertension, hypercholesterolemia, and chronic…
Hypothalamic control of brown adipose tissue thermogenesis
Abstract It has long been known, in large part from animal studies, that the control of brown adipose tissue (BAT)…
Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling
Abstract One of the unique features of prenatal alcohol exposure in humans is impaired cognitive and behavioral function resulting from…
HIV-1, methamphetamine and astrocytes at neuroinflammatory Crossroads
Abstract As a popular psychostimulant, methamphetamine (METH) use leads to long-lasting, strong euphoric effects. While METH abuse is common in…
Pathophysiology of anorexia in the cancer cachexia syndrome
Abstract Anorexia is commonly present in persons with cancer and a major component of cancer cachexia. There are multiple causes…