Designer drugs: mechanism of action and adverse effects
Abstract Electronic supplementary material: The online version of this article (10.1007/s00204-020-02693-7) contains supplementary material, which is available to authorized users.…
Review Article
Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant
Abstract Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the discovery of phytocannabinoids,…
Potential Adverse Drug Events with Tetrahydrocannabinol (THC) Due to Drug–Drug Interactions
Abstract Tetrahydrocannabinol (THC) is the primary psychoactive ingredient in cannabis. While the safety of THC and cannabis has been extrapolated…
Cannabidiol: A Brief Review of Its Therapeutic and Pharmacologic Efficacy in the Management of Joint Disease
Abstract Cannabis use in the management of musculoskeletal diseases has gained advocacy since several states have legalized its recreational use.…
Cannabis use and the sperm epigenome: a budding concern?
Abstract The United States is swiftly moving toward increased legalization of medical and recreational cannabis. Currently considered the most commonly…
Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases—focusing on FAAH/MAGL inhibitors
Abstract The endocannabinoid system (ECS) has received extensive attention for its neuroprotective effect on the brain. This system comprises endocannabinoids,…
Neurobiological Trajectories Involving Social Isolation in PTSD: A Systematic Review
Abstract Social isolation (SI) stress has been recognized as a major risk factor of morbidity in humans and animals, exerting…
Cannabinoids, Blood–Brain Barrier, and Brain Disposition
Abstract Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are based on their activity as analgesics, anti-emetics,…
Reviewing the Potential of Psychedelics for the Treatment of PTSD
Abstract There are few medications with demonstrated efficacy for the treatment of posttraumatic stress disorder (PTSD). Treatment guidelines have unequivocally…
From sunscreens to medicines: Can a dissipation hypothesis explain the beneficial aspects of many plant compounds?
Abstract Medicine has utilised plant‐based treatments for millennia, but precisely how they work is unclear. One approach is to use…