Endocannabinoid System and Tumour Microenvironment: New Intertwined Connections for Anticancer Approaches
Abstract The tumour microenvironment (TME) is now recognised as a hallmark of cancer, since tumour:stroma crosstalk supports the key steps…
Review Article
A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19
Abstract During the COVID-19 pandemic lasting now for well more than a year, nearly 247 million cases have been diagnosed…
The Effect of Marijuana on the Incidence and Evolution of Male Infertility: A Systematic Review
Abstract Over the past decade, the consumption of marijuana or any other form of cannabis, whether medically, recreationally, or illegally,…
Involvement of the ACE2/Ang-(1–7)/MasR Axis in Pulmonary Fibrosis: Implications for COVID-19
Abstract Pulmonary fibrosis is a chronic, fibrotic lung disease affecting 3 million people worldwide. The ACE2/Ang-(1–7)/MasR axis is of interest…
Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment
Abstract Despite the importance of pain as a warning physiological system, chronic neuropathic pain is frequently caused by damage in…
Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses
Abstract The medicinal use of Cannabis sativa L. can be traced back thousands of years to ancient China and Egypt.…
The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies
Abstract Currently, there are no pharmacological treatments able to reverse nigral degeneration in Parkinson’s disease (PD), hence the unmet need…
Endoscopic management of difficult common bile duct stones: Where are we now? A comprehensive review
Abstract Endoscopic management for difficult common bile duct (CBD) stones still presents a challenge for several reasons, including anatomic anomalies,…
Antimicrobial and Antiviral (SARS-CoV-2) Potential of Cannabinoids and Cannabis sativa: A Comprehensive Review
Abstract Antimicrobial resistance has emerged as a global health crisis and, therefore, new drug discovery is a paramount need. Cannabis…
15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
Abstract 15-lipoxygenase is one of the key enzymes for the metabolism of unsaturated fatty acids that its manipulation has been…