Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses
Abstract The medicinal use of Cannabis sativa L. can be traced back thousands of years to ancient China and Egypt.…
Review Article
The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies
Abstract Currently, there are no pharmacological treatments able to reverse nigral degeneration in Parkinson’s disease (PD), hence the unmet need…
Endoscopic management of difficult common bile duct stones: Where are we now? A comprehensive review
Abstract Endoscopic management for difficult common bile duct (CBD) stones still presents a challenge for several reasons, including anatomic anomalies,…
Antimicrobial and Antiviral (SARS-CoV-2) Potential of Cannabinoids and Cannabis sativa: A Comprehensive Review
Abstract Antimicrobial resistance has emerged as a global health crisis and, therefore, new drug discovery is a paramount need. Cannabis…
15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged sword
Abstract 15-lipoxygenase is one of the key enzymes for the metabolism of unsaturated fatty acids that its manipulation has been…
Efficacy of cannabis-based medications compared to placebo for the treatment of chronic neuropathic pain: a systematic review with meta-analysis
Abstract Background: Chronic neuropathic pain (NP) presents therapeutic challenges. Interest in the use of cannabis-based medications has outpaced the knowledge…
Probing Isoform Switching Events in Various Cancer Types: Lessons From Pan-Cancer Studies
Abstract Alternative splicing is an essential regulatory mechanism for gene expression in mammalian cells contributing to protein, cellular, and species…
Gene-Environment Interactions in Schizophrenia: A Literature Review
Abstract Schizophrenia is a devastating mental illness with a strong genetic component that is the subject of extensive research. Despite…
Cannabis-Based Medicines and Medical Cannabis for Chronic Neuropathic Pain
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s40263-021-00879-w. Authors: Frank Petzke ⚬, Thomas Tölle ⚬, Mary-Ann…
Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers
Abstract The dysregulation of mRNA translation is common in malignancies and may lead to tumorigenesis and progression. Eukaryotic initiation factor…