Cannabinoids in Chronic Pain: Clinical Outcomes, Adverse Effects and Legal Challenges
Abstract Cannabinoids have gained increasing attention as potential therapeutic agents in chronic pain management. Their mechanisms of action, mediated through…
Review Article
Practical approach to the safe use of cannabidiol in patients with refractory epilepsy: a mini review
Abstract Drug-resistant epilepsy (DRE), characterized by seizures that are unresponsive to the use of two or more conventional anti-seizure medication…
A Meta-Narrative Review of Channelopathies and Cannabis: Mechanistic, Epidemiologic, and Forensic Insights into Arrhythmia and Sudden Cardiac Death
Abstract Although cannabinoids have proven therapeutic benefits, they are increasingly known for their capacity to disturb cardiac electrophysiology, particularly in…
CD93 in Health and Disease: Bridging Physiological Functions and Clinical Applications
Abstract CD93 is a highly glycosylated transmembrane glycoprotein with key functional domains, including a C-type lectin-like domain (CTLD) and epidermal…
Evolving Strategies for the Optimal Management of Common Bile Duct Stones
Abstract Management of common bile duct (CBD) stones has evolved substantially with the advent of endoscopic techniques and dedicated high-end…
A systematic review of protein post-translational modifications in sepsis
Abstract Background: Sepsis originates from the host’s dysregulated response to pathogens, and its pathophysiological mechanisms are extremely complex. Recent research…
Cannabis use in adolescence and young adulthood and its effects on brain structure and function: a scoping review
Abstract Introduction: Adolescence and young adulthood are simultaneously periods of significant brain development and the ages in which people often…
Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization
Abstract Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the…
Genetic and Mechanistic Insights Inform Amyotrophic Lateral Sclerosis Treatment and Symptomatic Management: Current and Emerging Therapeutics and Clinical Trial Design Considerations
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting both upper and lower motor neurons. ALS is classically…
Management and Prevention of Neurodegenerative Disorders: Can Antioxidant-Rich Dietary Interventions Help?
Abstract Neurodegenerative diseases are associated with the senescence of functional neurons, which hampers brain functions. These diseases are caused by…