Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease
Abstract Background and Objective: Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B…
Research Article
HIV and HCV Screening, and Pre-Exposure Prophylaxis Among Managed Care Beneficiaries with Substance Use Disorders: A Cross-Sectional Study from a Single State
Abstract Purpose: Screening for HIV and Hepatitis C (HCV) is critical in caring for individuals with substance use disorders (SUD).…
Attention deficit hyperactivity disorder symptoms and risky sexual behaviours in university students:the i-Share study
Abstract Background: Risky sexual behaviours (RSB) and attention deficit hyperactivity disorder (ADHD) are both major concerns among university students. However,…
Consumption patterns and withdrawal symptoms in dual cannabis-tobacco users in Spain: Cross-sectional study
Abstract Cannabis and tobacco co-use is common in people starting treatment for cannabis problems. Most participants consumed cannabis mixed with…
Methylation Status of the DAT1 Dopamine Transporter Gene in Individuals With Cannabis Use Disorder: Associations With Personality Traits
Abstract Cannabis use is a growing public health concern due to its neuropsychiatric consequences and potential epigenetic effects. This study…
An Exploratory Typology of Tobacco-Related Misleading Content on Social Media: Qualitative Analysis of Instagram and TikTok
Abstract Background: Tobacco-related misinformation on social media platforms presents growing challenges to digital health communication and public health. Although prior…
Computational drug repositioning approach to predict multi-target therapeutics for epilepsy
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-27625-2. Article type: Research Article Keywords: AED, Drug repurposing/Repositioning,…
Comparative analysis of 105 datasets across species and tissues reveals differential transcriptomic responses to cannabinoids THC and CBD
Abstract Background: Cannabis use is on the rise yet the systematic molecular impact of key cannabinoid components on various tissues…
Neuropathic Pain and Related Depression in Mice: The Effect of a Terpene and a Minor Cannabinoid in Combination
Abstract Background/Objectives: Neuropathic pain is one of the most severe types of chronic pain. Although it is difficult to manage,…
Safety of Drugs Used in Difficult-to-Treat Epileptic Syndromes: A Disproportionality Analysis Using the Eudravigilance Database
Abstract Background/Objectives: Difficult-to-treat epileptic syndromes include conditions typically emerging in the first years of life and are characterized by a…