Phytocannabinoids Stimulate Rejuvenation and Prevent Cellular Senescence in Human Dermal Fibroblasts
Abstract In light of the increased popularity of phytocannabinoids (pCBs) and their appearance in beauty products without rigorous research on…
Research Article
Development and Validation of the LC–MS/MS Method for Determination of 130 Natural and Synthetic Cannabinoids in Cannabis Oil
Abstract Dietary supplements are widely available products used by millions of people around the world. Unfortunately, the procedure of adding…
GABAergic Neurotransmission in Human Tissues Is Modulated by Cannabidiol
Abstract Recently, the potential use of phytocannabinoids (pCBs) to treat different pathological conditions has attracted great attention in the scientific…
Discovery of a pyrano[2,3-b]pyridine derivative YX-2102 as a cannabinoid receptor 2 agonist for alleviating lung fibrosis
Abstract Background: Pharmacological modulation of cannabinoid 2 receptor (CB2R) is a promising therapeutic strategy for pulmonary fibrosis (PF). Thus, to…
Overpoliced and Underrepresented: Perspectives on Cannabis Legalization From Members of Racialized Communities in Canada
Abstract Historically, overpolicing of some racialized and Indigenous groups in Canada has resulted in unequal application of drug laws contributing…
Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function
Abstract TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here, we combine calcium imaging and patch-clamp electrophysiology with…
Specific polysubstance use patterns predict relapse among patients entering opioid use disorder treatment
Abstract Polysubstance use patterns over the 28-days pre OUD treatment were identified. Polysubstance use patterns were differentially related to relapse…
Integrative Analysis of Proteome-wide Association Studies and Functional Enrichment Analysis to Identify Genes and Chemicals Associated with Alcohol Dependence
Abstract Methods: Using data from published alcohol dependence genome-wide association studies, we first conducted a proteome-wide association study of alcohol…
Hemp Shives as a Raw Material for the Production of Particleboards
Abstract Increased demand for wood affects its price and thus contributes to the growing interest in raw materials that can…
A Randomized, Triple-Blind, Comparator-Controlled Parallel Study Investigating the Pharmacokinetics of Cannabidiol and Tetrahydrocannabinol in a Novel Delivery System, Solutech, in Association with Cannabis Use History
Abstract Background: An oral route of administration for tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) eliminates the harmful effects of smoking and…