Burden and trends of drug use disorders in young adults: global insights from GBD 2021
Abstract Background: Drug use disorders (DUDs) is a serious global health crisis, particularly affecting adolescents and young people. The increasing…
Research Article
Endoscopic Ultrasound‐Directed Transgastric ERCP in Patients With Roux‐En‐Y Gastric Bypass: A Multicenter Prospective Cohort Study (EDGE‐Pilot)
Abstract Objectives: Endoscopic retrograde cholangiopancreatography (ERCP) is frequently indicated in patients who underwent Roux‐en‐Y gastric bypass (RYGB) surgery. Endoscopic ultrasound‐directed…
Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis
Abstract Pediatric papillary thyroid carcinoma (PPTC) has exhibited a progressive increase in incidence in recent years, characterized by heightened biological…
Public understanding of medical cannabis in Poland 7 years after legalization: findings from a cross-sectional study
Abstract Background: Medical cannabis has been legally available in Poland since 2017, yet its integration into routine clinical practice remains…
Amazonian Cyanobacteria as a Source of Bioactive Compounds With Antimicrobial and Cytotoxic Properties
Abstract Cyanobacteria are photosynthetic microorganisms known for producing diverse bioactive compounds. This study explores the bioactivity of extracts and fractions…
First Report on some N2O2‐Donor Sets Tetradentate Schiff Base and Its Metal Complexes: Characterization and Antimicrobial Investigation
Abstract The new Schiff base ligand N,N′‐thiophene‐(bis‐1‐ethyl‐6,8‐difluoro‐7‐(3‐methylpiperazin‐1‐yl)‐4‐oxo‐1,4‐dihydroquinoline‐3‐carboxylic acid) (H2L) was synthesized via condensation of thiophene‐2,5‐diamine with lomefloxacin in ethanol using…
Physicochemical Study of a Germplasm Collection of Pea (Pisum sativum L.) Landraces From the Canary Islands
Abstract The Canary Islands have a wide variety of pea landraces (Pisum sativum L.), preserved by the Tenerife Genebank, with…
ZDHHC5 as a central regulator in a palmitoylation-associated prognostic model for lung adenocarcinoma: insights from pan-cancer and experimental analyses
Abstract Background: Protein S-palmitoylation is a reversible post-translational modification that plays a significant role in tumor progression. However, the impact…
Characterization of the Use and Perceptions of Cannabis for Mental Health in Older Canadians: A Cross-Sectional Analysis
Abstract Older adults are increasingly using cannabis medicinally, including for the treatment of mental health symptoms. The purpose of this…
Development and validation of a necroptosis-related gene signature for predicting prognosis and immune infiltration in papillary thyroid cancer
Abstract Background: Papillary thyroid cancer (PTC) accounts for over 80–85% of all thyroid malignancies and presents a rising global incidence.…