Dynamics of gut metabolome and microbiota maturation during early life
Abstract Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects…
Research Article
Pan-cancer multi-omics profiling reveals ubiquitin D as a novel biomarker for diagnosis, immune microenvironment remodeling and prognostic prediction
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-025-03545-5. Article type: Research Article Keywords: Ubiquitin D (UBD),…
Identification of immunological and prognostic value of SHROOM2 in pan-cancer and experimental verification of its role in promoting malignant phenotypes in breast cancer
Abstract Objective: This study aimed to investigate the relationship between Shroom Family Member 2 (SHROOM2) expression and immune features, survival…
scKAN: interpretable single-cell analysis for cell-type-specific gene discovery and drug repurposing via Kolmogorov-Arnold networks
Abstract Background: Analysis of single-cell RNA sequencing (scRNA-seq) data has revolutionized our understanding of cellular heterogeneity, yet current approaches face…
CDC6 as a pan-cancer immunological and prognostic biomarker and its role in suppressing melanoma malignancy
Abstract Background: Cell division cycle 6 (CDC6) is a key licensing factor for DNA replication in the G1 and S…
Pan‐cancer analysis reveals molecular signatures for predicting matrix stiffness in solid tumors
Abstract Tumor matrix stiffness plays a critical role in cancer progression, metastasis, and therapy resistance. Although traditional biophysical methods have…
Pan-cancer evaluation of ABAT as an emerging biomarker and its implication in lung adenocarcinoma
Abstract Background: 4-aminobutyric acid aminotransferase (ABAT) is a pivotal enzyme for mitochondrial metabolism and central nervous system homeostasis, with known…
Prevalence of AAS‐Positive Samples at Drug Abuse Laboratory Sweden Between 2014 and 2023 and Sub‐Study of Dual Use of AAS and Narcotics
Abstract It is of interest to investigate trends in AAS usage profile. Here we aimed to retrospectively study the prevalence…
Burden and trends of drug use disorders in young adults: global insights from GBD 2021
Abstract Background: Drug use disorders (DUDs) is a serious global health crisis, particularly affecting adolescents and young people. The increasing…
Severe maternal outcomes in 36 West African hospitals from Benin, Burkina Faso and Niger
Abstract Background: Maternal mortality has been used as the major indicator of maternal health for more than thirty years, but…