In vitro inhibition of voltage-dependent sodium currents by the antifungal drug amorolfine
Abstract Voltage-gated sodium (Nav) channels are critical for electrical signaling, and their pharmacological modulation can be leveraged for the development…
Research Article
APOA1 promotes tumor proliferation and migration and may be a potential pan-cancer biomarker and immunotherapy target
Abstract APOA1 was aberrantly expressed in a multitude of tumor types and exhibited variability across various tumor stages. Overexpression of…
State funding for cannabis research: an analysis of funding mechanisms and levels
Abstract Background: This paper examines cannabis research funding across U.S. states that have legalized cannabis for medical or adult (non-medical)…
Region-Specific Impact of Repeated Synthetic Cannabinoid Exposure and Withdrawal on Endocannabinoid Signaling, Gliosis, and Inflammatory Markers in the Prefrontal Cortex and Hippocampus
Abstract Synthetic cannabinoid use raises concerns about its neuroinflammatory effects, including molecular adaptations of the endocannabinoid system (ECS) in the…
UK Medical Cannabis Registry: An Analysis of Outcomes of Medical Cannabis Therapy for Hypermobility‐Associated Chronic Pain
Abstract Objective: The study aims to evaluate the clinical outcomes in patients with hypermobility spectrum disorder (HSD) and hypermobile Ehlers–Danlos…
Beyond Borders: A Longitudinal Study of Nepali Nurses’ Dreams, Realities, and the Pursuit of a Global Career
Abstract The global migration of nurses, particularly from developing nations like Nepal, is a complex tapestry woven with threads of…
Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies
Abstract Background: Tauopathies represent a diverse group of neurodegenerative disorders characterized by the abnormal aggregation of the microtubule-associated protein tau.…
Mapping and characterization of a novel powdery mildew resistance locus (PM2) in Cannabis sativa L.
Abstract Introduction: Breeding genetic resistance to economically important crop diseases is the most sustainable strategy for disease management and enhancing…
Cannabidiol-Based Thiosemicarbazones: A Preliminary Study Evaluating Their Anti-Tyrosinase Properties
Abstract Cannabidiol (CBD), a non-psychoactive cannabinoid, has attracted significant research interest due to its antioxidant, anti-inflammatory, and neuroprotective properties. As…
Identification of TAP2 as a novel immune target in human cancers: insights from integrated bioinformatics and experimental approaches
Abstract Background: Transporter 2, ATP binding cassette (ABC) subfamily B member (TAP2), encodes a protein within the ABC transporter superfamily.…