A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1
Abstract Anti-CRISPRs (Acrs) are natural inhibitors of bacteria’s CRISPR-Cas systems, and have been developed as a safeguard to reduce the…
X-ray crystallography
Biophysical Studies and In Vitro Effects of Tumor Cell Lines of Cannabidiol and Its Cyclodextrin Inclusion Complexes
Abstract Phytocannabinoids possess anticancer properties, as established in vitro and in vivo. However, they are characterized by high lipophilicity. To…
Defining molecular glues with a dual-nanobody cannabidiol sensor
Abstract “Molecular glue” (MG) is a term coined to describe the mechanism of action of the plant hormone auxin and…
Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif
Abstract Apolipoprotein L1 (ApoL1) is a circulating innate immunity protein protecting against trypanosome infection. However, two ApoL1 coding variants are…
The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
Abstract Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome in a process requiring the RNA helicase Mtr4…
Insights into SusCD-mediated glycan import by a prominent gut symbiont
Abstract In Bacteroidetes, one of the dominant phyla of the mammalian gut, active uptake of large nutrients across the outer…
Crystal structure of higher plant heme oxygenase-1 and its mechanism of interaction with ferredoxin
Abstract Heme oxygenase (HO) converts heme to carbon monoxide, biliverdin, and free iron, products that are essential in cellular redox…
Mechanism of self/nonself-discrimination in Brassica self-incompatibility
Abstract Self-incompatibility (SI) is a breeding system that promotes cross-fertilization. In Brassica, pollen rejection is induced by a haplotype-specific interaction…
Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering
Abstract Myosin VI plays crucial roles in diverse cellular processes. In autophagy, Myosin VI can facilitate the maturation of autophagosomes…
FABP1 controls hepatic transport and biotransformation of Δ9-THC
Abstract The increasing use of medical marijuana highlights the importance of developing a better understanding of cannabinoid metabolism. Phytocannabinoids, including…