Digital profiling of gene expression from histology images with linearized attention
Abstract Cancer is a heterogeneous disease requiring costly genetic profiling for better understanding and management. Recent advances in deep learning…
Tumour heterogeneity
An elevated rate of whole-genome duplications in cancers from Black patients
Abstract In the United States, Black individuals have higher rates of cancer mortality than any other racial group. Here, we…
Pan-cancer analysis reveals correlation between RAB3B expression and tumor heterogeneity, immune microenvironment, and prognosis in multiple cancers
Abstract RAB3B is essential for the transportation and secretion within cells. Its increased expression is linked to the development and…
Exploring the advances of single-cell RNA sequencing in thyroid cancer: a narrative review
Abstract Thyroid cancer, a prevalent form of endocrine malignancy, has witnessed a substantial increase in occurrence in recent decades. To…
Research progress and application of single-cell sequencing in head and neck malignant tumors
Abstract Single-cell sequencing (SCS) is a technology that separates thousands of cells from the organism and accurately analyzes the genetic…
Cancer genomes tolerate deleterious coding mutations through somatic copy number amplifications of wild-type regions
Abstract Cancers evolve under the accumulation of thousands of somatic mutations and chromosomal aberrations. While most coding mutations are deleterious,…
An algorithm to quantify intratumor heterogeneity based on alterations of gene expression profiles
Abstract Intratumor heterogeneity (ITH) is a biomarker of tumor progression, metastasis, and immune evasion. Previous studies evaluated ITH mostly based…
Divergent mutational processes distinguish hypoxic and normoxic tumours
Abstract Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular…