Dysregulation of Locus-Specific Repetitive Elements in TCGA Pan-Cancers
Abstract Background: Understanding the role of repetitive elements (REs) in cancer development is crucial for identifying novel biomarkers and therapeutic…
tumor suppressor gene
New insights into the dule roles CDK12 in human cancers: Mechanisms and interventions for cancer therapy
Abstract The dysregulation of cyclin-dependent kinase 12 (CDK12), which may result from genomic alterations or modulation by upstream effectors, is…
Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12967-024-05326-0. Article type: Research Article Keywords: Oncogene, Tumor suppressor,…
FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression
Abstract Background: FLI1 is an oncogenic transcription factor that promotes diverse malignancies through mechanisms that are not fully understood. Herein,…
GLIPR2: a potential biomarker and therapeutic target unveiled – Insights from extensive pan-cancer analyses, with a spotlight on lung adenocarcinoma
Abstract Background: Glioma pathogenesis related-2 (GLIPR2), an emerging Golgi membrane protein implicated in autophagy, has received limited attention in current…
Systematic integration of protein-affecting mutations, gene fusions, and copy number alterations into a comprehensive somatic mutational profile
Abstract Somatic mutations occur as random genetic changes in genes through protein-affecting mutations (PAMs), gene fusions, or copy number alterations…
Does the LHPP gene share a common biological function in pancancer progression?
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12920-022-01396-5. Article type: Research Article Keywords: LHPP, Tumor suppressor,…
Death-Associated Protein Kinase 1 Inhibits Progression of Thyroid Cancer by Regulating Stem Cell Markers
Abstract The activation of metastatic reprogramming is vital for cancer metastasis, but little is known about its mechanism. This study…
EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling
Abstract Background: Somatic mutations are involved in hepatocellular carcinoma (HCC) progression, but the genetic mechanism associated to hepatocarcinogenesis remains poorly…
Integrative omics analysis reveals relationships of genes with synthetic lethal interactions through a pan-cancer analysis
Keywords: ACC, adrenocortical carcinoma, BLCA, bladder urothelial carcinoma, BRCA, breast invasive carcinoma, CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma,…